Cell Press Editors will screen the comments to ensure that they are relevant and appropriate but comments will...doi:10.1016/0167-5699(87)90031-4T.V. RajanElsevier B.V.Immunology TodayRajan, T. V (1987) Is there a role for MHC class I antigens in the elimination of somatic mutants?
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However, these studies were based on data collected from the literature, dealt with host species that were not simultaneously surveyed both for parasites and MHC alleles, and did not consider the functional diversity of alleles. More importantly, the way interactions among hosts and parasites are ...
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there is a growing view that the Ca2+transients are the culmination of the integrative actions of many cellular processes and likely involve new and previously not considered components. A greater understanding of the contribution of these processes to the normal Ca2+transients is likely to alter ho...
But there's also this, if you prefer to view it this way: Will Betts be overpaid when he's 37, 38, 39 years old? Sure, probably. But he's likely to be underpaid to start. It'll even out, even if you don't really want him manning right field in 2032. That is, if you assu...
While similarities exist between the HLA class I and HLA class II presentation pathways, there are also key differences that distinguish these pathways. HLA class I peptide ligands are presented to CD8+ T-cells and predominantly sourced endogenously, from peptides that arise from intracellular ...
However, GI-101A tumor growth analysis upon VACV-infection in either immunosuppressed nude mice (MHCII+-cell depleted) or in immune-deficient mouse strains (T-, B-, NK-cell-deficient) revealed that neither MHCII-positive immune cells nor T-, B-, or NK cells contributed significantly to ...
Here, using fluorescent CSF tracers in Prox1-GFP lymphatic reporter mice18, we found that the nasopharyngeal lymphatic plexus is a major hub for CSF outflow to deep cervical lymph nodes. This plexus had unusual valves and short lymphangions but no smooth-muscle coverage, whereas downstream deep...
Furthermore, there is no obvious way of safely delivering AOX to affected tissues as a protein without eliciting an immune reaction; nor is there any certainty of avoiding the risks of insertional mutagenesis when introducing it in DNA form. Using cmRNA as a vehicle avoids both problems. Our ...