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Indeed, MVBs are often seen in the vicinity of the ER and may represent extensions of smooth ER.32 Similarly, the Golgi is a major site of Aβ generation in the secretory pathway and MVBs also are Golgi associated (Figure 1E).32 We also observed Aβ42 in very small vesicles that may...
1a, b) and induced alternative autophagy by the addition of etoposide, a DNA-damaging reagent. As described previously5, the ultrastructural analysis demonstrated the etoposide-induced formation of autophagosomes (double-membrane structures) and autolysosomes (single-membrane structures digesting subcellular...
We hypothesized that the alpha subunit of hemoglobin expressed in endothelium also facilitates nitrite reduction proximal to smooth muscle. Here, we create two mouse strains to test this: an endothelial-specific alpha globin knockout (EC Hba1Δ/Δ) and another with an alpha globin allele mutated ...
anti- ADCY8 antibody规 格 0.2ml/200μg 1ml/1mgThis is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence(By similarity).adenylate cyclase 8(brain) anti- Adenosine A1 Receptor antibody抗体来源 RabbitADORA1, also named as RDC...
With the full support and care of the hospital, the department of cardiovascular surgery II organized several multidisciplinary, domestic and international joint consultations to ensure the smooth progress of this difficult surgery. Participants in the online consultation were cardiac surgery experts from ...
In the nervous system, the sphingolipid metabolism has an important impact. Neurons are polarized cells and their normal functions, such as neuronal connectivity and synaptic transmission, rely on selective trafficking of molecules across plasma membrane. Sphingolipids are abundant on neural cellular ...
The most commonly used drugs to control the formation and function of lipid drafts are nystatin and filipin which sequester cholesterol, MβCD which is used to deplete membrane-bound cholesterol, and lovastatin which inhibits cholesterol biosynthesis [8]. Recent reports have demonstrated the ...
THEMIS plays an indispensable role in T cells, but its mechanism of action has remained highly controversial. Using the systematic proximity labeling methodology PEPSI, we identify THEMIS as an uncharacterized substrate for the phosphatase SHP1. Saturated mutagenesis assays and mass spectrometry analysis ...
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+-mobilizing second messenger which uniquely mobilizes Ca2+ from acidic endolysosomal organelles. However, the molecular identity of the NAADP receptor remains unknown. Given the necess