In the original crystal structure 6M0J and in no-EF simulations, the aromatic residue from Phe456 is in close contact (less than 6 Å) with Tyr473 and the amino group of Lys 417, which leads to a very important stabilising internal \(\pi\)-cation interaction52. Application of an ...
each playing a role in making the molecule polar. The main part of its shape is a thioether function group - sulfur joined to two alkyl parts. This special sulfur-holding part sets methionine apart from other amino acids. Methionine has an amino group, a carboxyl group and a methyl group ...
The synthesis of customized glycoconjugates constitutes a major goal for biocatalysis. To this end, engineered glycosidases have received great attention and, among them, thioglycoligases have proved useful to connect carbohydrates to non-sugar acceptors
Two amino acid ionic liquids (AAILs) were investigated by molecular dynamics simulation to get effect of polar group at bulk of liquid and adsorb layer of electric double layer. Hydrogen bond plays an important role in this evaluation. Polar group changed hydrogen bond site of the pure bulk. ...
(A1-type)43. Of note, within the phylum of Campylobacterota, we found all four subunits of caa3-type oxidase in the genome ofSulfurovumsp. AR derived from aerobic Arctic sediments44. This oxidase has an amino acid identity of 70% to that ofUS. pluma. However, this caa3-type oxidase ...
The union of the aminopyridyl side chain 15 with thiazoloalcohol 8 was facilitated by reacting the two compounds in the presence of KI in acetonitrile, and this alkylation was followed by removal of the Boc group with hydrochloric acid to give rise to isavuconazonium iodide hydrochloride (16)...
Article Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target Graphical abstract Authors Matthias Paulus Wagner, Pauline Formaglio, Olivier Gorgette, ..., Rogerio Amino, Lhousseine Touqui, Chetan E. Chitn...
To test the hypothesis that bacterial YhhN proteins also function as lysoplasmalogenase enzymes, we cloned the Lpg1991 gene of Legionella pneumophila, which encodes a 216 amino acid YhhN protein (LpYhhN), and expressed it in Escherichia coli as a C-terminal-GFP-His8-fusion. Membranes were ...
For volatile organic compounds (VOCs) to be released from the plant cell into the atmosphere, they have to cross the plasma membrane, the cell wall, and the cuticle. However, how these hydrophobic compounds cross the hydrophilic cell wall is largely unkn
The incorporation of RhB into a dfTAT analog has been reported to generate a non-fluorescent delivery tool (RhB loses fluorescence upon conjugation)23. DEAC is a coumarin-based fluorophore. X was also used to introduce a single canonical amino acid residue (F, Y, W), two residues (LL, ...