telomerasesomatic cellstumorigenesisStudies have reported that the telomerase could be detected in a majority of human tumor tissues, but not in most normal tissues. In tumorigenesis, the activation of telomeraseseems to be an important step for somatic cells to gain the ability of indefinite ...
a我是你唯一永远的天使 I am you only forever angel [translate] aTelomerase is inactivated in normal human epithelial tissue, but is reactivated in neoplasia Telomerase在正常人的上皮组织在瘤形成被撤消,但恢复活动 [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语翻译 西班牙...
The human telomerase RNA subunit is expressed in all three tissues at all gestational ages examined. hTERT expression correlates with telomerase activity in the liver, where both are expressed at all ages surveyed, and in the heart, where both are present until the 11th gestational week but not...
Telomerase Repeat Amplification Protocol (TRAP): A New Molecular Marker for Parathyroid Carcinoma Telomerase results to be active in human germ, stem cells, several malignant cell tumors and in immortalized cell lines. In order to investigate if molecul... A Falchetti,L Becherini,V Martineti,.....
In contrast, most transformed cells including cancer cells maintain short but stable telomeres by activating telomerase. Therefore, the telomere maintenance along with telomerase activation has been suggested as a general mechanism of tumorigenesis.8 Telomeres are known to form a loop structure or a t...
The lengths of human telomeres, which protect chromosome ends from degradation and end fusions, are crucial determinants of cell lifespan. During embryogenesis and in cancer, the telomerase enzyme counteracts telomeric DNA shortening. As shown in cancer cells, human telomerase binds the shelterin ...
Telomerase activity (TA) is associated with most malignant human tumors but is not detected in normal somatic cells with a few exceptions. Three major subu... BK Lee,E Diebel,FW Neukam,... - 《International Journal of Oncology》 被引量: 72发表: 2001年 Telomeres, telomerase and colorectal ...
Several telomerase-negative immortal human cell lines were reported, in which telomerase-independent mechanisms was supposed to maintain telomere length. We aimed at seeing whether the telomerase-negative phenotype of these immortal cells is dominant over telomerase-positive phenotype of other immortal ...
A universal characteristic of eukaryotic transcription is that the promoter recruits RNA polymerase II (RNAPII) to produce both precursor mRNAs (pre-mRNAs) and short unstable promoter upstream transcripts (PROMPTs) toward the opposite direction. However,
We found that AT-101 induces apoptosis in both human leukemia cell lines and primary human leukemia cells, and also inhibits tumor growth of U937 xenograft mouse model via RhoA/ROCK1/PTEN signaling, Akt inactivation, Mcl-1 downregulation, Bcl-2-associated death promoter (Bad) dephosphorylation, ...