All tissues contained active telomerase, most abundantly in testis, spleen, liver, and embryos; activity was less abundant but still readily detectable with < 100 ng of protein extract from brain and muscle tissues. Activity in somatic tissues of the diploid Xenopus tropicalis suggests this ...
A TIN2 mutant extends telomeres in telomerase-positive cells,14 suggesting that TIN2 also controls the telomere length. Manipulation of the telomere-binding protein gene expression reveals that alterations in those proteins can impair the function of the telomere and induce senescence.9, 12, 14, ...
Involvement of the retinoblastoma susceptibility (RB-1), p16INK4, p53 and telomerase genes in immortalisation was examined by determining their status in 15 human cell lines representing four immortalisation complementation groups. No abnormalities of RB-1, p53 and p16INK4 were detected in cell ...
For instance, it was noted that hyperglycemia causes stress-induced premature senescence and replicative senescence of endothelial cells and decreased their telomerase activity. On the other hand, insulin preserved telomere length and delayed endothelial senescence even in the presence of hyperglycemia. Insu...
A universal characteristic of eukaryotic transcription is that the promoter recruits RNA polymerase II (RNAPII) to produce both precursor mRNAs (pre-mRNAs) and short unstable promoter upstream transcripts (PROMPTs) toward the opposite direction. However,
porcine hemagglutinat porcine proliferative porcine telomerasete porcine thrombomoduli pore bridging pore cluster pore porosity pore restriction pore-wall curvature porebodyradius porepre ure porg pork beef pork chops pork dawn garlic sauc pork floss spring oni pork porridge pork rib w noodle pork ro...
Why do cells perform mitosis? Why are all different parts of the cell necessary? What is the role of killer T-cells in apoptosis? What is the purpose of cell transport? Why is telomerase not active in somatic cells? Why does a cell undergo mitosis? What cell types can somatic cells diff...
In the somatic cells of several vertebrates, telomerase expression is downregulated at the end of embryogenesis, leading to progressive TL shortening throughout the life course. In other organisms, telomerase expression is maintained throughout life5,6,7, and TL does not decrease with age8. In ...
Extension of life-span by introduction of telomerase into normal human cells Science, 279 (1998), pp. 349-352 View in ScopusGoogle Scholar [35] M. Nomoto, H. Izumi, T. Ise, K. Kato, H. Takano, G. Nagatani, K. Shibao, R. Ohta, T. Imamura, M. Kuwano, K. Matsuo, Y. Yamada...
Auranofin (AF), a gold (I)-containing phosphine compound, is being investigated for oncological application as a repurposed drug. We show here that 4~5 µM AF induces paraptosis, a non-apoptotic cell death mode characterized by dilation of the endop