Wright2 Rifampin (RIF) phosphotransferase (RPH) confers antibiotic resistance by conversion of RIF and ATP, to inactive phospho-RIF, AMP and Pi. Here we present the crystal structure of RPH from Listeria monocytogenes (RPH-Lm), which reveals that the enzyme is comprised of three domains: two ...
Of the four standard TB antibiotics used in “short course” treatment (HRZE), only Rifampin, which inhibits bacterial RNA polymerase, is a broad-spectrum antimicrobial that is used for non-mycobacterial infections. The effects of this prolonged antibiotic regimen on the intestinal microbiota are ...
rifampin rifampicin rifamycin antibiotic resistance resistome Streptomyces RNA polymerase superfamily 1 helicase helicase-like protein photoaffinity labeling Sorry, something went wrong. Please try again and make sure cookies are enabled Data and code availability ...
Rifampin is usually part of a 6-month treatment for tuberculosis. The potential for strategies employing shorter initial treatment phases to lead to comparable outcomes is unclear.This open-label, non-inferiority, adaptive trial randomly assigned individuals with rifampin-susceptible pulmonary tuberculosis ...
We have treated 4-year-old with amikacin and rifampin, who suffered from bacterial meningitis due to gentamicin-resistant Pseudomonas aeruginosa. There was no complication during treatment. Even though we didint check audiometry and BUN and/or creatinine, urinalysis was normal and physical examination...
47. Piccaro, G., Pietraforte, D., Giannoni, F., Mustazzolu, A. & Fattorini, L. Rifampin Induces Hydroxyl Radical Formation in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy 58, 7527–7533 (2014). 48. Kumar, A. et al. Redox homeostasis in mycobacteria: the key to ...
antibiotic treatment. Time to footpad swelling in mice treated with either rifampin + streptomycin for 5 weeks (gray circles) or 6 weeks (black triangles), or TB47 for 1 week (red square) or for 2 weeks (purple triangle). Statistical differences were determined by Log-rank (Mantel-...