Our results demonstrate the potential to rescue the large number of available OM-excluded antibiotics to target normally resistant Gram-negative bacteria via synergistic action with these cationic polyurethanes, acting as a novel antibiotic adjuvant class....
Description Rifampicin is a semisynthetic derivative of rifamicin B, a macrolactam antibiotic and one of more than five antibiotics from a mixture of rifamicins A, B, C, D, and E, which is called a rifamicin complex, which is produced by actinomycetes Streptomyces mediteranei (Nocardia med...
The compound is not considered a carcinogen under typical therapeutic conditions, but like many antibiotics, misuse or overuse can contribute to the development of resistant strains of bacteria. Rifampicin should be stored in a cool, dry, and well-ventilated area, protected from light and moisture...
Bacteria have cross resistance to rifamycin class antibiotics. Rifampicin and dependent on DNA, RNA polymerase beta subunit solid combination, inhibit bacterial RNA synthesis, prevent the enzyme connected with DNA, thereby blocking process of RNA transcription, DNA a...
Bacteria have cross-resistance to rifamycin antibiotics.Rifampicin binds firmly to the β subunit of DNA-dependent RNA polymerase, inhibits the synthesis of bacterial RNA and prevents the enzyme from connecting with DNA, thereby blocking the RNA transcription process and stopping the synthesis of DNA ...
Background: Reasonable use of antibiotics postoperatively is widely recognized as one of the effective ways to prevent periprosthetic joint infection after total hip arthroplasty. However, at present there is no consensus in the best kind of antibiotics, sole or collective use, the best dosage and...
The RNA polymerase of Gram-negative and Gram-positive bacteria are similarly sensitive to rifampicin, but the MICs for Gram-negative bacteria are higher because of reduced penetration of rifampicin through their outer cell membrane. The reason for antagonism between rifampicin and antibiotics which act...
There is no change in sensitivity of rho mutants to the antibiotics penicillin, erythromycin, chloramphenicol, or the detergent desoxycholate. The rho-101 or rho-102 mutations confer rifampicin supersensitivity at 32°C but not 42°C. Mutants of a rho-115 strain that have lost polarity ...
Since the second part of the twentieth century, the industrialization of pharmacotherapy, the development of antimicrobial chemotherapy and the introduction of new antibiotics (streptomycin, isoniazid, para-aminosalicylic acid, ethambutol and pyrazinamide) deeply revolutionized treatment for tuberculosis, ...
Antibiotics for Scale-Up Cell Culture, Antimycobacterial, Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecules, Cell Biology, Cell Culture Supplies, Cell Signaling and Neuroscience, Chemical Structure Class, Core Bioreagents, DNA-RNA Transcription Regulators, Gene Regulation and Expression...