GENETIC testingMETASTATIC breast cancerSINGLE-strand DNA breaksCOMING of ageDNA mismatch repairCHECKPOINT kinase 2CASTRATION-resistant prostate cancerCombination therapy has now become a new standard of care for de novo metastatic PCa in the wake of several landmark combination therapy trials...
Prostate cancer is the third most common cancer, accounting for one in 10 cancer diagnoses in men worldwide during 2000. Despite this high burden of morbidity, there is a lack of curative treatments for locally advanced and metastatic disease. Good anatomical accessibility of the prostate combined ...
Prostate tumors derived from cases with the GT/GG genotypes had significantly lower levels ofmRNA when compared with cases with the TT genotypes (=0.02).Our results indicate that the genetic variation of rs3753793 in thepromoter may contribute to genetic predisposition to PCa and intra-tumor ...
The exact cause of prostate cancer is unknown. Most prostate cancers happen by chance, or due to shared environmental and common genetic factors. But what we do know is that prostate cancer happens when some prostate cells become abnormal. Abnormal cells grow and multiply more quickly than normal...
Is prostate cancer invasive? What is the prostate cancer screening test called? Is prostate cancer genetic? Is stage 3 prostate cancer treatable? Is prostate cancer curable if it has spread? How long is radiation treatment for prostate cancer?
Prostate Cancer: Advances in Genetic Testing and Clinical Implications The demand for genetic testing (GT) for prostate cancer (PCa) is expanding, but there is limited knowledge about the genetic counseling (GC) needs of men. ... AS Abdelrazek,K Ghoniem,ME Ahmed,... - Uro 被引量: 0发表...
Organoid technology has greatly expanded our ability to model epithelial biology, including prostate cancer19,20. Previously, we described a strategy to assess genetic drivers of prostate adenocarcinoma (PRAD), as well as cells of origin using mouse prostate organoids coupled with orthotopic transplantat...
Researchers have identified a genetic signature in localized prostate cancer that can predict whether the cancer is likely to spread, or metastasize, early in the course of the disease and whether it will respond to anti-androgen therapy, a common treatm
How I Do It: Genetic counseling and genetic testing for inherited prostate cancer. Prostate cancer has a substantial heritable component, which is often under-appreciated in the urologic community. Inherited prostate cancer which may acco...
Cancer Research UK scientists have for the first time identified that there are five distinct types of prostate cancer and found a way to distinguish between them, according to a landmark study published today in EBioMedicine.