Cancer syndrome is a condition where genetic mutations that increase the risk of cancer are inherited. Explore what cancer syndrome is and its role in cancer at a young age, discover some clues to help detect if cancer developed due to this condition, a...
Fifth, it is possible that normal but genetically defined vari- ation in the expression of metabolic enzymes could influence cancer risk and progression. Microarray analysis of gene ex- pression in cells from healthy individuals has shown that some metabolic enzymes and transporters are highly ...
is also postulated [25,26]. An inherited predisposition for breast cancer is noticed in males-analogous to that in females [27–31]. A positive family history of a first-degree female relative having breast cancer is seen in up to 15–20% patients [32]. This increased risk is conferred ...
DOMINANTLY INHERITED OSTEOGENESIS IMPERFECTA (OI TYPES I AND IV) IS GENETICALLY LINKED TO THE COLIAI AND CJL1A2 GENES OF TYPE I COLLAGENOsteogenesis imperfecta (OI) is a genetically heterogeneous group of connective tissue disorders. Mutations in Type I collagen have been shown in a number of ...
(2005), which may evoke the impression that this mutation has something to do with prostate cancer. In reality, this mutation occurs in many parts of the mtDNA phylogeny and had already been observed prior to 2005 in the coding-region data of Herrnstadt et al. (2002, 2003) and in the ...
Insufficient male hormones for a fetus that's genetically male or the presence of male hormones for a fetus that is genetically female Specific genes that have mutated and influenced sex development Abnormalities in a fetus’ chromosomes, like an absent or extra chromosome ...
`U' trial is first to test gene therapy in patient with a rare inherited illness; Researchers hope that genetically altered cells from a patient will help him battle Hunter syndrome, a hereditary disorder. Success could lead the way to gene therapies against such illnesses as heart disease and...
The progressively older population in developed countries is reflected in an increase in the number of people suffering from age-related chronic inflammatory diseases such as metabolic syndrome, diabetes, heart and lung diseases, cancer, osteoporosis, ar
The search for the cause of an inherited form of a rare, aggressive childhood lung cancer has uncovered important information about how the cancer develops and potentially sheds light on the development of other cancers. Ad The finding by researchers at Washington University School of Medicine in ...
doi:10.1038/bjc.2012.329 www.bjcancer.com Published online 9 August 2012 & 2012 Cancer Research UK Keywords: colorectal cancer; TERT–CLPTM1L; rs2736100 Many colorectal cancers (CRCs) develop in genetically susceptible individuals most of whom are not carriers of germ-line mismatch repair or APC...