One of the world's first phage therapy studies conducted on osteoarticular infections on prostheses caused by Staphylococcus aureus infections was recently approved by the French Drug Safety Agency (ANSM). The Phase 2 study PhagoDAIR involves a panel of 64 patients with hip or knee joint infectio...
A non-pathogenic ECHO virus has been registered for use in several Eastern European countries, an attenu- ated adenovirus has been registered for use in China and a modified herpes virus (HSV-1) was approved by the FDA and EMA in 2015 and is now used routinely for cer- tain melanomas ...
It should, however, be noted that some phages are able to transfer bacterial genes by transduction, a factor that must be taken into consideration during the early stage of phage selection. A comprehensive analysis of theoretical advantages of phages over antibiotics, together with some of their l...
Belimumab, an anti-BAFF antibody, is a representative of B-cell-targeted therapy approved for treating SLE.32 Belimumab, targets only B cells, therefore, we hypothesized that 2D4 would be more effective in treating SLE than Belimumab. To test this hypothesis, we compared the efficacy of the ...
Kymriah (Tisagenlecleucel) is recognized as the FDA's first-ever approved CAR-T cell immunotherapy treatment. Cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, adverse events potentially associated with CAR-T cell therapy, are classified and graded according to a ...
2003 https://pubchem.ncbi.nlm.nih.gov/patent/US-2006257852-A1 SARS Coronavirus-2 was patented in 2015 https://patents.google.com/patent/US20200279585A1/en the SARS CoV-2 “Vaccine” is not a “Vaccine”; it is a non-FDA Approved, man-made, experimental injectable medical gene therapy. ...
Immune receptor In 58 cases (46.4% of the total), actionable genetic mutations compatible with FDA-approved drugs were identified, precisely matching their tumor's histological profile. Additionally, 47 (37.6%) further samples showed a different assortment of genetic alterations. A median overall ...
approved by the FDA in 2011, marked a significant milestone as the first new drug for SLE in over 50 years, it did not achieve disease improvement and flare reduction endpoints in 40–50% of SLE patients during trials.39The intricate pathogenesis of SLE involves not only B-cell disorders bu...
The CELLSEARCH® System is the first case that has been approved for clinical use by the Food and Drug Administration (FDA) and enables the detection and follow-up of cancer cells in the blood by observing the expression of epithelial cell adhesion molecule (EpCAM) and cytokeratin, which are...
Antibody-drug conjugates (ADCs) have recently seen proof-of-concept clinical success in Hodgkin lymphoma and breast cancer, but none is yet FDA-approved for MM. The CD46 gene is located on the long arm of chromosome 1 (1q32.2), 50Mbp from a FISH probe clinically used to identify high-...