Phage therapy, the use of bacteriophage viruses for bacterial infection treatment, has been around for almost a century, but with the increase in antibiotic use, its importance has declined rapidly. There has been renewed interest in revisiting this practice due to the general decline in the effec...
Bacteriophage therapy destroys bacteria in a species- or strain-specific manner. Classified as lytic or temperate, bacteriophages may propagate antibiotic resistance if temperate bacteriophages are employed. Utilized more in Eastern Europe than in the United States or in the European Union, lytic ...
Phage therapyimplementation in the United States and western Europe has met numerous obstacles.104More than two decades following its reappraisal by the West, no phase III disease-treatmentclinical trialshave been conducted.104,105Apart from previously discussed intrinsic challenges of phage therapy, seve...
Vibrio parahaemolyticusis pathogenic to both humans and marine animals. Antimicrobial-resistant (AMR) bacteria have been reported to cause mortalities in shrimp, with phage therapy presenting an alternative and eco-friendly biocontrol strategy for controlling bacterial diseases. Therefore, this study aimed ...
Phage therapy for plant disease controlwith a focus on fire blight1917, who independently reported on filterable and transmissible agents of bacterial lysis [27]. In spite of the promising early results of phage therapy, the discovery of broad-spectrum activity antibiotics in the 1940s resulted in...
Our results have implications for the design and application of phage therapy and reveal a mechanism for how microbial functions that are deleterious to human and environmental health can proliferate in the absence of positive selection.Similar content being viewed by others Slow growing bacteria ...
In terms of pharmaceutical classification in EU and United States, phages are considered as anti-infectious medicinal products and biological products, given the intended use and their live nature. During the production steps, the compliance with the Good Manufacturing Practice (GMP) represents the ...
A Betts,O Kaltz,ME Hochberg - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 66发表: 2014年 Experimental evolution and bacterial resistance: (co)evolutionary costs and trade-offs as opportunities in phage therapy research Antagonistic coevolution between...
Although bacteriophages are not pathogenic to mammalian cells, they induce a humoral immune response in a mammalian host resulting in the formation of anti-phage antibodies that can influence the effect of phage therapy. We detail the experiences of several centers in Poland, the Republic of ...
“If you look at the early Nobel Prizes in molecular biology, half of the awards went to researchers using phages,” NIMH’s Merril says. The work also helped researchers understand the shortcomings of phage therapy of the past. Some of the preparations were contaminated. On top of that, ea...