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The tissue-specific self- pathogen is the protective self-antigen: the case of uveitis. J Immunol. 2002;169:5971-7.Mizrahi T, Hauben E, Schwartz M (2002) The tissue-specific self- pathogen is the protective self-antigen: the case of uveitis. J Immunol 169:5971-5977...
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal APOE4 in AD pathogenesis is still unclear. Here
The sexually transmitted bacterium Neisseria gonorrhoeae (also referred to as the gonococcus, Ngo) is a human-restricted pathogen that typically establishes an infection within the cervix, which links the vagina to the uterus. Infections that remain localized here are generally asymptomatic; however, ...
(PH) genes in any database other than VFDB. Six CDSs had 66.6–72.1% identity and 65.7–93.5% coverage to homologous targets in VFDB. Three out of those six CDSs with homologues in the VFDB database were also assigned to PH pathways by KAAS: two to O-antigen nucleotide sugar ...
Moreover, ArgD evoked a robust antibody response in immunized mice, suggesting it to be a potent B cell antigen. Together, our results suggest that ArgD of M. tuberculosis is a multifunctional protein exploited by the bacterium to modulate host-pathogen interaction and immune modulation. 2. ...
All mice were on a pure C57BL/6 genetic background and were housed in a pathogen-free barrier facility on a 12-h light cycle at 19–23 °C and 30–70% humidity. Animals were identified by ear punch under brief isoflurane anesthesia and genotyped by PCR of a tail clipping. All ...
Peptidoglycan (PG), a structural component of the bacterial cell wall and a highly conserved pathogen-associated molecular pattern (PAMP), has been shown to trigger inflammatory responses in both Lyme arthritis (LA) and rheumatoid arthritis (RA) [17,18,19]. PG is recognized by innate immune ...
Sta ph. epidermidis is a common fo reign body pathogen, particu larly of pl ast i c int ravenous cat heters . Many strai ns i solated fro m infect ed IV cath et er s produce a loos el y adherent sli me feres ma t er with ial, human whi ch we have PMN chemotaxi s.pre...
Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its metabolic requirements. Here we show that OSKM reprogramming in mice causes a g