The [3H]palmitic acid labeling of pro-TNF was eliminated by treatment with hydroxylamine, indicating that the labeling was due to palmitoylation of a cysteine residue via a thioester bond. Site-directed mutagenesis of the two cysteine residues residing in the leader sequence of pro-TNF demonstrated...
Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N‑acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress Yang He, Lingyun Zhou, Zhiqiang Fan, Shikun Liu & Weijin Fang Cell Death & Disease volume 9, Article num...
羧基PEG棕榈酸是纳米双功能反应性脂质PEG衍生物之一,棕榈酸是一种具有优异疏水性的16碳饱和脂肪酸脂质。PEG修饰的棕榈酸是一种优良的两亲性聚合物,这些材料可以通过用靶向配体如抗体、肽修饰其表面来用于靶向药物递送。 CarboxyPEG palmitic acid is one of the nano bifunctional reactive lipid PEG derivatives. Pa...
Pinolenic Acid Downregulates Anabolic Pathway of Lipid Metabolism in HepG2 Cells Pine nut oil has been reported to attenuate hepatic triglyceride accumulation. However, effect of pinolenic acid (18:3, all-cis-螖5,9,12), a unique component of pine nut oil, on hepatic lipid metabolism has not...
A low metabolic flexibility to lipid (MetF-lip) in skeletal muscle may promote ectopic lipid accumulation, thus inducing metabolic disturbances. We aimed to determine the association between MetF-lip in skeletal muscle and metabolic health outcomes in in
It should be noted that all plant GlcADG species with acyl groups consisting of 34 carbons have a palmitic acid moiety at the sn-2 position (Supplementary Fig. S3). Palmitic acid (16:0 fatty acid) is a minor acyl group both in galactolipids and at sn-2 of phos- pholipids, but it ...
The digestion and absorption of dietary glycerol tri(1-14C)oleate and oleic acid-1-14C and subsequent transport of the label was followed during the fifth instar in Pieris brassicae. The rate of incorporation of the label in tissue lipid... S Turunen - 《Journal of Insect Physiology》 被引...
(FGF21) has shown promising weight- and lipid-lowering potential in rodent models of obesity and is being investigated for NAFLD [84; Table 1], however the large molecular mass and complex tertiary structure of FGF21 make it somewhat unattractive as a therapeutic due to heightened production ...
Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered lipids that are conserved from yeast to mammals1,2. A subfamily, palmitic acid esters of hydroxy stearic acids (PAHSAs), are anti-inflammatory and anti-diabetic1,3. Humans and mice with insulin resistance...
Notably, Rictor-required genes in the PPAR signaling pathway encode regulators of both anabolic and catabolic lipid metabolism such as fatty acid uptake, fatty acid oxidation, DNL, and TAG synthesis (Figure S2A). By comparing the D8 Rictor-required genes with a published database of PPARγ ...