Fremion, F., Darboux, I., Diano, M., Hipeau-Jacquotte, R., Seeger, M.A., Piovant, M., 2000. Amalgam is a ligand for the transmembrane receptor neurotactin and is required for neurotactin-mediated cell adhesion and axon fasciculation in Drosophila. EMBO J. 19, 4463-4472....
CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1. Eur J Immunol 2000;30:2130-7... ElizabethF. Vernon-Wilson,WJ Kee,AntonyC. Willis,... - 《European Journal of Immunology》 被引量: 313发表: 2000年 CD47 is a ligand for rat macr...
2, cells expressing ApoER2 (A) or VLDLR (B) bind significant amounts of labeled clusterin nicely decorating the entire cell membrane. Because of the experimental conditions (4 °C), the bound ligand remained on the cell surface. This effect is receptor specific, since control experiments with...
the LD50 virus led to direct infection of lung NK cells and impairment of their cytotoxicity and IFN-γ production, which is a strong enhancer of the CTL-mediated immune response.36 As introduced previously, NK cells can accelerate the initiation and exemplification of the T-cell response by ...
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor residing in the cytoplasm in the form of a multiprotein complex. Following ligand binding, the receptor dissociates from the complex and translocates into the nucleus where it initiates transcription of various genes (in ...
wherein L2 is a ligand other than an L1 ligand, Mn is the transition metal manganese, and x is a positive number at least equal to about 0.5. 2. A process of forming self-condensation products of a phenol having the structural formula: ##SPC5## where X is a substituent selected from...
We identified several sequence variants with a strong effect on AITD risk (Fig.1b). Two of these are in the same gene,LAG3; a rare 5′-UTR variant (rs781745126-T, OR = 3.42,P = 2.2 × 10−16) and a missense variant (rs149722682-A, Pro67Thr, OR = 2.11,...
Correlation analysis showed a significant association between CD72 and PD-L1 (CD274) and CTLA4. Pd 1 and CTLA4 are two key immune checkpoint molecules with essential roles in regulating T-cell function and activating [81,82]. When Pd-L1 (ligand for Pd 1) and CTLA4 are upregulated, tumor ...
Stimulation by CpG ODN2006, a ligand for Toll-like receptor 9 (TLR9), did not affect this downregulation of IL-22BP expression (Figure 9a). Similar results were obtained after stimulation of DCs by other TLR ligands (including ligands for TLRs 1–6, 7, and 8) (data not shown). In ...
To study the biological function of AtACINUS, we obtained two mutant lines that contain T-DNA insertions in the exons ofAtACINUS,Salk_078554andWiscDsLoxHs108_01G, which are designatedacinus-1andacinus-2, respectively (Fig.1c). These mutants showed no obvious morphological phenotypes except slig...