Ligand-field strengths are conveniently expressed by the empirical spectrochemical series. Although cyanide has been deeply entrenched as a strong-field ligand, a couple of recent examples cast doubt toward the
Although over one hundred halogenated monoterpenes have been isolated and characterized from field collections of red macroalgae, their biogenesis is poorly understood. Studies suggest that ocimene is the common precursor to all halogenated monoterpenes found in Plocamium, whereas myrcene is the common ...
Constitutive eCB signaling constrains anxiety, as acute pharmacological disruption of eCB function rapidly produces a state of anxiety [44,45,46]. Similarly, exposure to stress is known to increase activity of the enzyme fatty acid amide hydrolase (FAAH), which metabolizes the eCB ligand anandamide...
Release of root exudates or downward movement of labile C in soils can lead to a ‘priming effect’—that is, a short-term increase in the rate of microbial decomposition of soil organic matter (SOM) resulting from fresh organic C input15,16(Table1), although field-based observations of th...
One compelling problem in this field is lack of information regarding the molecular basis of mPTP and its relationship with other mitochondrial channels like MAC and VDAC. Even though our direct studies of mitochondrial channels are somewhat limited, these channels are, nevertheless, emerging as ...
However, a major barrier to the development and success of immunotherapy in patients with HCC is the liver’s inherent immunosuppressive function. Recent advances in the field of cancer immunology allowed further characterization of immune cell subsets and function, and created new opportunities for ...
The “comet assay” provides a simple and effective method for evaluation of DNA damage and DNA-repair capacity in single cells such as leucocytes. The principle of the assay is based upon the ability of DNA fragments to migrate out of the cell under the influence of an electric field. An...
those composing the skin (Figure2, upper row). HPF did not yield a signal (not shown), suggesting that the ROS detected with DCFDA were weak oxidants, such as H2O2. The merge of the pictures obtained recording DCFDA/SOSG and chlorophylls fluorescence signals superimposed to the bright field...
Synaptic dysfunction plays a central role in Alzheimer’s disease (AD), since it drives the cognitive decline. An association between a polymorphism of the adenosine A2A receptor (A2AR) encoding gene—ADORA2A, and hippocampal volume in AD patients was re
In addition, ligand-bound p62 induces autophagosome biogenesis. Through this dual regulation, cells can synchronize the accumulation of autophagic cargoes to p62 activation and autophagosome biogenesis in a timely fashion. Our results suggest that p62 is a key molecule in the crosstalk between the UPS...