Ligand-field strengths are conveniently expressed by the empirical spectrochemical series. Although cyanide has been deeply entrenched as a strong-field ligand, a couple of recent examples cast doubt toward the position of this ligand, namely the high-spin (S = 2) states of [Cr(II)(CN)(5)...
Irina A. Guschina, John L. Harwood Some red algae (an example is Gracilariopsis lemaneiformis) metabolize 20C acids via 8-, 9- or 12-lipoxygenase (LOX)-initiated pathways, whereas other species contain oxylipins of the eicosanoid family produced by 5R-, 8R-, 9S-, 12S- and 15S-lip...
Constitutive eCB signaling constrains anxiety, as acute pharmacological disruption of eCB function rapidly produces a state of anxiety [44,45,46]. Similarly, exposure to stress is known to increase activity of the enzyme fatty acid amide hydrolase (FAAH), which metabolizes the eCB ligand anandamide...
In addition, ligand-bound p62 induces autophagosome biogenesis. Through this dual regulation, cells can synchronize the accumulation of autophagic cargoes to p62 activation and autophagosome biogenesis in a timely fashion. Our results suggest that p62 is a key molecule in the crosstalk between the UPS...
Left: data are reported as mean number ± SEM of 8-OH-dG+ nuclei per field. Right: representative immunofluorescence images are shown. (E and F) Immunofluorescence analysis of γ-H2Ax (E) and 53BP1 (F) 15 days after 3-MCA injection in Ptx3+/+ and Ptx3−/− mice treated with ...
Oxidised nicotinamide adenine dinucleotide (NAD+) is essential as a coenzyme in oxidoreductase reactions, and it functions as a consumed ligand in, for example, sirtuin- and poly(ADP-ribose) polymerase-related activities [1,2]. Dietary intake of vitamin B3, which exists in various forms, and ...
However, a major barrier to the development and success of immunotherapy in patients with HCC is the liver’s inherent immunosuppressive function. Recent advances in the field of cancer immunology allowed further characterization of immune cell subsets and function, and created new opportunities for ...
those composing the skin (Figure2, upper row). HPF did not yield a signal (not shown), suggesting that the ROS detected with DCFDA were weak oxidants, such as H2O2. The merge of the pictures obtained recording DCFDA/SOSG and chlorophylls fluorescence signals superimposed to the bright field...
Driver mutations in the AR ligand-binding domain have been linked to antiandrogen resistance, but only a small percentage of patients carry these mutations [6]. Additionally, AR variants, particularly AR-V7, have been suggested to be partially responsible for restoring AR signaling [5, 10, 33]...
Taken together, these findings provided strong evidence supporting a role of Slc6a4/SERT in controlling the glutamatergic synaptic drive of the PFC-to-raphe circuit. Fig. 4 Lack of SERT increases the number of functional PFC-to-DRN synapses. a rAAV-CAG-hChR2(H134R)-mCherry was bilaterally...