With ethyl chloride, interaction of the LUMO lobe on the C-Cl carbon with HOMO of incoming nucleophile leads to nucleophilic substitution reaction at the sp3 carbon with inversion of configuration (SN2 reaction). Intuitively, this leads to the question, can vinyl chloride undergo a similar in-...
we repeated the force-quench experiments at pH=7.2 using the small thiol 3-mercapto-1-propanol as the attacking nucleophile41(Supplementary Fig. 11). In this case, the rupture of each individual disulfide bond resulted in the formation of a thiolate and the newly formed mixed disulfide. Unlike...