26K Neurological disorders are diseases that affect an individual's brain or cognition. Review a list of common problems such as dementia, epilepsy, stroke, multiple sclerosis (MS), Parkinson's, and dangerous infections, then explore descriptions of each type of disease. Related...
Multiple sclerosis (MS) is a chronic autoimmune disease that damages the protective covering around nerves in the brain and spinal cord due to inflammation. In areas of the brain and spinal cord affected by MS, signals transmitted across nerves are slowed or blocked, causing neurological symp...
Multiple sclerosis (MS) is a potentially debilitating disease affecting the central nervous system (CNS) clinically characterized by progressive neurological deterioration. It is the most common condition under the umbrella of demyelinating disease, thought to occur as a result of a primary autoimmune ...
In the mouse model of multiple sclerosis (MS), experi- mental autoimmune encephalomyelitis (EAE), IDO fosters Th cell differentiation towards a regulatory phenotype and its inhibition or genetic ablation exacerbates the disease15–17. Similar to IDO, TDO catabolizes trp although its expression ...
Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination, neurodegeneration, accumulating neurological dysfunction in the central nervous system (CNS). MS affects approximately 2.8 million people worldwide, which is one of the most common causes of non-traumatic disability in young...
Oligodendrocytes (OLs) produce and maintain the myelin sheaths around axons, making fast and economical communication between distant neurons possible. Axonal health is crucial for brain function, and axonal damage is a feature of aging and various neurological disorders1,2. Accumulating evidence reveals...
Accordingly, it has been demonstrated that intra-CSF administration of seminal vesicle fluid from Wistar rats can ameliorate clinical sign of a female Lewis rat model of experimental autoimmune encephalomyelitis (EAE), the animal model of MS. The results indicated an up-regulation of FoxP3 ...
Patients with DPN can develop length-depend- ent sensorimotor polyneuropathy, the pathogenic char- acteristics of which include persistent hyperglycaemia, microvascular dysfunction, oxidative and nitrosative stress, neurotrophic deficiencies, and autoimmune-medi- ated neurological destruction [16, 17]. ...
However, autoimmune diseases involving cytokines are usually associated with single gene defects, whereas the KD profile suggests more polygenic influence [31]. Ultimately, KD can be recognized as a complex inflammatory syndrome that occasionally affects the CAs of patients with genetic predisposition and...
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal APOE4 in AD pathogenesis is still unclear. Here