Is bipolar disorder a neurological disease? Is Down syndrome a neurological disease? Is schizophrenia a neurodegenerative disease? Does MS cause degenerative disc disease? Is amyotrophic lateral sclerosis fatal? Does MS cause spinal stenosis? Are neurological disorders mental illnesses?
Is glioblastoma a neurodegenerative disease? What type of neurological disease is MS? How do prions cause neurodegenerative disease? What disease mimics myasthenia gravis? What is traumatic brain disease? What are the symptoms of microvascular brain disease? What are systemic neurological disorders? Is ...
Inhibitors of histone deacetylase (HDAC) enzymes have been shown to improve learning and memory; however, multiple forms of HDAC exist, and the development of more effective HDAC inhibitors would benefit from knowing the specific HDAC(s) that are involved in the regulation of synaptic plasticity. ...
People with psychotic disorders show abnormalities in several organ systems in addition to the central nervous system (CNS); and this contributes to excess mortality. However, it is unclear how strong the evidence is for alterations in non-CNS systems at the onset of psychosis, how the alteration...
Our complete NGS solutions are uniquely suited to research in understanding how the combination of genetics and the environment influence development of complex diseases such as autoimmune disorders, neurodegenerative diseases, and many others. Human identification (HID) ...
Collectively, based on our group analysis which showed that MDS-OAβ was lower in AD dementia than in A-PET-positive MCI patients, MDS-OAβ could be closely linked with earlier neurodegenerative processes in the AD continuum. The detrimental downstream cascade of neurodegeneration after the disease...
Neurodegenerative disorders are marked by extensive neuronal apoptosis and gliosis. Although several apoptosis-inducing agents have been described, underst... A Jana,EL Hogan,K Pahan - 《Journal of the Neurological Sciences》 被引量: 247发表: 2009年 AMPA glutamate receptor-mediated calcium signaling...
Changes in such excitatory inputs to spinal motoneurons may have important implications for hyperreflexia and/or glutamate-induced excitotoxicity in the neurodegenerative disease amyotrophic lateral sclerosis (ALS). With the use of the G127X SOD1 mutant mouse, an ALS model with a prolonged ...
Single-nucleus RNA-sequencing revealed that the removal of neuronal APOE4 greatly diminished neurodegenerative disease-associated subpopulations of neurons, oligodendrocytes, astrocytes and microglia whose accumulation correlated to the severity of tau pathology, neurodegeneration and myelin deficits. Thus, ...
Resting-state functional scans (rs-fMRI) were acquired by an EPI sequence over 10 min with the following parameters: TR = 2000 ms, TE = 30 ms, FA = 80°, 3 × 3 × 3 mm voxes. A total of 300 volumes were acquired per scan. 11C-PBR28 PET 11C-...