aTGF-β is a key factor produced by macrophages challenged with apoptotic cell remnants, which as such could represent a relevant source of the cytokine. TGF-β是巨噬细胞导致的一个关键系数挑战与apoptotic细胞残余,作为这样可能代表cytokine的一个相关的来源。[translate]...
Metabolic Stress in the Immune Function of T Cells, Macrophages and Dendritic Cells Innate and adaptive immune cells from myeloid and lymphoid lineages resolve host infection or cell stress by mounting an appropriate and durable immune res... D Charlotte,L Lydia,F Benjamin - 《Cells》 被引量: ...
Ly-6C- cultured monocytes and Ly-6C- monocyte-like cell lines, but not fully differentiated macrophages and macrophage-like cell lines, can be induced to express the Ly-6C antigen by interferon-gamma. A population of small vessel endothelial cells in diverse tissues also express high levels of...
While memory cells were the dominant T cell reservoir, integrated HIV-1 DNA was also detected in the BM and spleen macrophages in both regimen-treated mice. Conclusion Despite vigorous ART regimens, HIV-1 DNA and RNA were easily detected in mature macrophages supporting their potential role as ...
We therefore verified this question further biochemically using macrophages, a cell type which is more relevant for innate immune signaling. We isolated LDs from THP-1 cells and primary human monocytes by flotation on a sucrose gradient58. Western blotting for RNF213 and LD marker proteins such ...
BEP, biomarker-evaluable population; FDR, false discovery rate; GSEA, gene set enrichment analysis; Mφ, macrophages; MHC I, major histocompatibility complex class I; OS, overall survival; TME, tumor microenvironment Full size image Taken together, patients with CD8Hi/MφHi exhibited the highest ...
Approaches to characterize cell types Cell types are the product of evolution Hierarchical organization of transcriptomically defined cell types Correspondence between transcriptomic cell types and other cellular properties Cell types versus cell states Cell type development How to define cell types? Acknowled...
Ischemic stroke induces delayed MANF protein expression in rat brain microglia/macrophages To evaluate whether MANF expression post-stroke is similar in rat as we have found in the human brain, we next characterized MANF protein immunostaining patterns in a rat model of dMCAo at 2, 7, 14, ...
colorectal carcinoma samples, lactate, which can be used as a surrogate for aerobic glycolysis, is negatively correlated with STING expression level and antitumour immunity. Taken together, this study reveals that STING functions as a cell-intrinsic metabolic checkpoint that restricts aerobic glycolysis ...
cell. Once the process is complete, the cell lyses and releases the mature spore into the environment. This is an enormous commitment for the bacterial cell in lieu of normal division. To put it into perspective, the average generation time for a vegetatively growingBacillusspecies can be as...