Silk cocoon of Bombyx mori: proteins and posttranslational modifications--heavy phosphorylation and evidence for lysine-mediated cross links. Although silk is used to produce textiles and serves as a valuable biomaterial in medicine, information on silk proteins of the cocoon is limited. Scanning......
L-lysine and L-tyrosine are just two of the many amino acids used by the body as building blocks for proteins and in various metabolic pathways.Each amino acid has a specific structure and corresponding function within the body. The exact roles of L-lysine and L-tyrosine are quite different...
This work not only provides a methodology for distinguishing other PTM isomers, but also highlights Kl-laas the primary responder to glycolysis and the Warburg effect.##Using a combination of antibody- and LC鈥揗S/MS-based methods, Zhang et al. reveal lysinel-lactylation as the key lacty...
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Mutations in enzymes that modify histone H3 at lysine 4 (H3K4) or lysine 36 (H3K36) have been linked to human disease, yet the role of these residues in mammals is unclear. We mutated K4 or K36 to alanine in the histone variant H3.3 and showed that the K4A mutation in mouse embryon...
1a)5,6. Similarly, in the biosynthesis of s56-p1, lysine is oxided to N6-hydroxylysine, and the N6-hydroxyl is then joined with the carboxyl group of glycine. The N–N bond is subsequently formed through intramolecular nucleophilic attack by the glycine amino group (Supplementary Fig. 1b)...
First, we identified and comprehensively validated Kglu as an evolutionarily conserved PTM. We then showed that SIRT5 catalyzes lysine deglutarylation both in vitro and in vivo. We further validated CPS1, the rate-limiting enzyme important for ammonia detoxification in urea cycle, as a glut...
The homologous regions include the conserved catalytic residues of iPLA2, including the GDSRG sequence, in which the arginine is replaced by a lysine in VipD. VipD has phospholipase A activity with diacyl glycerophospholipid substrates [34]; plasmalogen was not tested as a substrate. If the ...
Coiled-coil domains of intermediate filaments (IF) and prokaryotic IF-like proteins enable oligomerisation and filamentation, and no additional function is ascribed to these coiled-coil domains. However, an IF-like protein from Streptomyces reticuli was
Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its metabolic requirements. Here we show that OSKM reprogramming in mice causes a g