Protein farnesyltransferase (FTase) catalyses the formation of a thioether linkage between proteins containing a C-terminal CaaX motif and a 15-carbon isoprenoid. The involvement of substrates such as oncogenic Ras proteins in tumour formation has led to intense efforts in targeting this enzyme for ...
Lysine is an amino acid found in nature, and which the human body has to get from food sources. As a building block of protein, it serves a number of different functions, and although deficiency is relatively uncommon, low levels can cause health problems. People sometimes use it in ...
Increase of intracellular Ca2+ in cultured mouse hippocampal neurons by trachynilysin, a protein toxin extracted from stonefish (Synanceia trachynis) venom La trachynilysine, une neurotoxine isolee du venin du poisson-pierre, Synanceia trachynis (Scorpaenidae), provoque une augmentation tres importan...
Wu X, Oh MH, Schwarz EM, Larue CT, Sivaguru M, Imai BS, Yau PM, Ort DR, Huber SC (2011) Lysine acetylation is a widespread protein modification for diverse proteins in Arabidopsis. Plant Physiol 155: 1769-1778X. Wu, M.H. Oh, E.M. Schwarz, C.T. Larue, M. Sivaguru, B.S. ...
Liu, B., Du, H., Rutkowski, R., Gartner, A. & Wang, X. LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science 337, 351–354 (2012). Article ADS CAS PubMed PubMed Central Google Scholar Liu, Y. et al. Autophagy-dependent ribosomal RNA de...
The transforming gene product encoded by Moloney murine sarcoma virus clone 124, p37mos, contains a lysine residue (lysine-121) that is conserved among all members of the protein kinase family. This lysine has been shown to be part of a conserved ATP-binding site in both the catalytic subunit...
Under a Creative Commons license Open accessLysine acetylation has recently emerged as an important, widespread post-translational modification occurring on proteins that reside in multiple cellular compartments, including the mitochondria. However, no lysine acetyltransferase (KAT) has been definitively locali...
Histone acetylation is a predominant active chromatin mark deposited by histone acetyltransferases (HATs) that transfer the acetyl group from acetyl coenzyme A (acetyl-CoA) to lysine ε-amino groups in histones. GENERAL CONTROL NON-REPRESSED PROTEIN 5 (GCN5) is one of the best-characterized HATs ...
[0002]细胞的生理功能大多是由蛋白‑蛋白相互作用(protein‑protein interactions,PPIs)介导的,因此对蛋白‑蛋白互作的分子机制研究一直是生命科学和基础医学研究领域的重要内容。 [0003]目前,已经开发了几种筛选PPIs的实验方法,包括酵母双杂交、免疫共沉淀(co‑immunoprecipitation,co‑IP)和蛋白质谱联用技术等,...
coli DNA protection during starvation protein (SK+114.0281DaATNLLYTR) with a mass shift of +114.0281Da at the lysine residue has the same MS/MS spectrum as that of the synthetic peptide with a glutaryl group on lysine residue (SKgluATNLLYTR) (Figure 2C). In addition, the in vivo-derived...