Bile from the hemojuvelin-deficient mouse model of iron excess is enriched in iron and ferritinhemochromatosishemojuvelinliverbileironferritinIron is an essential nutrient but is toxic in excess. Iron deficiency is the most prevalent nutritional deficiency and typically linked to inadequate intake. Iron ...
Through TCGA database analysis, we enriched the gene and found that SLC25A19 is closely related to ferroptosis and immune infiltration. In vitro experiments have shown that silencing SLC25A19 can significantly inhibit the proliferation and migration ability of liver cancer cells. In addition, after...
Ferroptosis is a unique cell death, dependent on iron and phospholipid peroxidation, involved in massive processes of physiopathology. Tremendous attention has been caught in oncology, particularly for those therapy-resistant cancers in the mesenchymal s
Compared with other organs, the liver is particularly enriched with cells of the innate immune system, likely a result of the fact it is the site where foreign antigens from the gastrointestinal tract first encounter the innate immune system defenses. The liver contains the largest pool of ...
More iron was enriched in tumors in the Fe(hino)3 group than in the vehicle group (Fig. 5E). And 4-Hydroxynonenal (4-HNE), an α, β-unsaturated hydroxyalkenal that is produced by lipid peroxidation, was significantly increased post-Fe(hino)3 administra- tion. This result was ...
on the enriched water volume, the time of H resin treatment, the dosage of AlCl3, and the duration of precipitation. The concluding optimization step for water treatment involves the application of 150 grams of Milli-Q-washed H resin to 10 liters of filtered water for 30 seconds, followed ...
Alveolar type II cells, which are appreciated as a cell of origin for lung adenocarcinoma64,65, are enriched with mitochondria to manage the highly oxygenated lung microenvironment66. This may contribute to the substantial mitochondrial metabolism exhibited by human lung tumors25,26 and the necessity...
a, Venn diagram illustrating the overlap of differentially expressed genes (DEGs) obtained by bulk RNA-seq and genes enriched in macrophages (left panel). Scatterplot of RNA-seq analysis from FAC-sorted CD63hi and CD63loβ cells. DEGs with a false discovery rate (FDR) < 0.05 are in...
What food is high in iron? Some of the best plant sources of iron are: Beans and lentils. Tofu. Baked potatoes. Cashews. Dark green leafy vegetables such as spinach. Fortified breakfast cereals. Whole-grain and enriched breads. Can vitamin D cause low iron?
We therefore performed an in-vitro histone H3 cleavage assay using purified CTSL and CTSB in an enriched nuclear fraction from healthy HT22 cells. While both enzymes were able to digest histone H3 in our in-vitro nuclear preparation, CTSB was a less efficient protease and displayed a unique ...