The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. J. Cell Biol. 156, 249-259.Kang D, Chen J, Wong J, Fang G. The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. ...
What does DNA ligase do? Why does DNA polymerase require a primer? Does RNA polymerase use a single-stranded DNA template? Why is it important for DNA polymerase to proofread? If RNA polymerase is responsible for separating DNA strands during transcription, then what does Helicase do?Explore...
Thus, the protein is presumed to act as a component of a ubiquitin ligase complex that specifically directs negatively acting factors in ABA signalling to degradation via the proteasome. 展开 关键词: ABA anthocyanin Arabidopsis de-etiolation EDL3 F-box protein flowering germination induction root ...
The/gene encodes a ubiquitin ligase implicated in the control of chromosome stability. Here we identify the mousegene as a p53-dependent tumour suppressor gene by using a mammalian genetic screen for p53-dependent genes involved in tumorigenesis. Radiation-induced lymphomas from p53mice, but not tho...
protein-coding in the FANTOM CAT database13, these results suggested a preference of LETR1 to interact with regulatory regions near protein-coding genes (fold enrichment = 3.24,Pvalue < 0.05). Therefore, we focused on the identified 1607 protein-coding genes displaying at least one ...
FACI is a phospholipid-binding protein that localizes to plasma membrane and recycling endosomes. Hepatic transcription of Faci was regulated by not only CREB-H, but also nutrient-responsive transcription factors sterol regulatory element-binding protein 1 (SREBP1), hepatocyte nuclear factor 4α (HNF...
XA21 is a receptor-like kinase protein in rice [Oryza sativa) that confers gene-for-gene resistance to specific races of the causal agent of bacterial blight disease, Xanthomonas oryzae pv oryzae. We identified XA21 binding protein 3 (XB3), an E3 ubiquitin ligase, as a substrate for the XA...
LC3/ATG8 has long been appreciated to play a central role in autophagy, by which a variety of cytoplasmic materials are delivered to lysosomes and eventually degraded. However, information on the molecular functions of LC3 in RNA biology is very limited.
We recently discovered that TRIM24, an E3-ubiquitin ligase, ubiquitinates and promotes proteasome-mediated degradation of p53. Here, we show that TRIM24 is destabilized by ATM-mediated phosphorylation of TRIM24S768 in response to DNA damage, which disrupts TRIM24-p53 interactions and promotes the...
Therefore, there may be vital members of the SCF E3 ubiquitin ligase family, which could drive pro-tumorigenesis. Being the largest family of E3 ubiquitin ligases, the SCF is composed of four components: SKP1, a cullin, an F-box protein, and RBX1 or RBX2. This multimeric complex is ...