We show for the first time, using infectious viruses, that BST-2 also inhibits egress of arenaviruses but has no effect on filovirus replication and spread. Specifically, infectious Lassa virus (LASV) release significantly decreased or increased in human cells in which BST-2 was either stably ...
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Both viral and host factors contribute to a variable outcome of arenavirus infection, ranging from virus control and clearance by the host defenses to chronic infection in the absence of clinical symptoms to severe disease (Buchmeier et al., 2007). Several arenaviruses, chiefly Lassa (LASV) ...
The AMPK inhibitor compound C inhibited infectious EBOV replication in Vero cells and diminished EBOV GP-dependent, but not Lassa fever virus GPC-dependent, entry into a variety of cell lines in a dose-dependent manner. Compound C also prevented EBOV GP-mediated infection of primary human ...
The sequestration of virus particles by BST-2 is not unique to HIV-1 and other retroviruses; BST-2 has been demonstrated to trap other enveloped viruses including KSHV, Lassa, as well as Ebola and Marburg virus-like particles (VLPs) (Jouvenet et al., 2009, Kaletsky et al., 2009, ...
is a recently discovered restriction factor that can limit virus replication. it blocks the release of a diverse spectrum of enveloped viruses, including primate lentiviruses, simple retroviruses, filoviruses, arenaviruses and rhabdoviruses [ 1 – 8 ]. cd317 causes mature virus particles to be ...
is a recently discovered restriction factor that can limit virus replication. it blocks the release of a diverse spectrum of enveloped viruses, including primate lentiviruses, simple retroviruses, filoviruses, arenaviruses and rhabdoviruses [ 1 – 8 ]. cd317 causes mature virus particles to be ...