It is suggested that significant conformational change(s) in the protein induced by NO binding to the heme lead to HRI activation. We discuss the role of NO and heme in catalysis by HRI, focusing on heme-based sensor proteins. 展开
Malaria is associated with haemolysis and the release of plasma haem. Plasma haem can cause endothelial injury and organ dysfunction, and is normally scavenged by haemopexin to limit toxicity. It was hypothesized that dysregulation of the haem-haemopexin pathway contributes to severe and fatal mala...
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While the discovery of bilirubin reductase illuminates a key gap in our understanding of the health-relevant steps of haem excretion, there are additional aspects of the pathway that require elucidation. First, while it is likely that bilirubin is deconjugated by beta-glucuronidases before it is r...
We conclude that there is a beneficial threshold of HO-1 overexpression related to the accumulation of reactive iron released in the degradation of heme. Therefore, despite the ready induction of HO-1 in oxidant stress, accumulation of reactive iron formed makes it unlikely that exaggerated ...
The octahaem cytochrome c MccA (also known as SirA) catalyses this reaction for dissimilatory sulfite utilization by various bacteria. It is distinct from known sulfite reductases because it has a substantially higher catalytic activity and a relatively low reactivity towards nitrite. The mechanistic ...
This Cys-heme cross-link is most likely the result of non-physiological oxidative radical reactions at the siroheme during aerobic purification, but still it indicates that the complex between DsrAB and DsrC is more stable in these organisms than in A. fulgidus, where obviously the two proteins...
Hemoglobin is made up of Haem pigment and globin proteins. It has been estimated that 1 gram of hemoglobin can carry up to 1.34 milliliters of oxygen.Answer and Explanation: Fetal hemoglobin is produced for upto 6 months before delivery. Fetal hemoglobin binds to ...
What is heme structure? chemical structure known as a heme group. Heme iscomposed of a ringlike organic compound known as a porphyrin, to which an iron atom is attached. It is the iron atom that reversibly binds oxygen as the blood travels between the lungs and the tissues. ...
Essentially, the previous work fell short because it did not test whether GAPDH heme binding is of central importance to its involvement. In fact, to date there has been no demonstration that GAPDH can even bind mitochondrially-generated heme in intact cells or whether such intracellular heme ...