Both peptides are toxic to cells in culture, and there is increasing evidence that early "soluble oligomers" are the toxic entity rather than mature amyloid fibrils. The molecular mechanisms responsible for this toxicity are not clear, but in the case of A, one prominent hypothesis is that ...
Hydrogen peroxide-induced poly(ADP-ribosyl)ation regulates osteogenic differentiation-associated cell death H2O2 is a key regulator of osteogenic differentiation of SAOS-2 and mesenchymal stem cells. H2O2 induces PARylation and cell death during osteogenic diffe... A Robaszkiewicz,K Erdélyi,K Kovács...
The log odds ratio represents the mean estimate of the change in the log odds of cells per sample from a given animal model, corresponding to a unit change in a given histopathological parameter. Negative associations are shown in blue and positive associations are shown in red. Unadjusted P ...
A major goal of cancer therapy concerns the selective targeting of tumor cells by anti-cancer agents. IAA is non-toxic at high doses and well tolerated by humans, and HRP is a stable enzyme which can target to tumor cells. Thus, several suggestions for the targeting of HRP have been ...
(∼8% by weight). However, the Al ion is highly toxic to plants. When soils become acidic, part of Al is solubilized from insoluble aluminosilicates or oxides to form soluble ions.1The resultant phytotoxic Al ions can rapidly enter root cells, and cause a series of cellular damages,2...
Dehydrogenase acts on toxic aldehydes and converts them into their less toxic intermediates inside cells and also reported for cleavage of ether bond [43, 44]. There are various dehydrogenases observed in this strain and these might play important role in ether linkage degradation. The dehydrogenase...
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat. Med. 24, 647–657 (2018). Article CAS PubMed PubMed Central Google Scholar Lin, Y.-T. et al. APOE4 causes widespread molecular and cellular alterations ...
In addition, stress factors, such as hyperoxia, hydrogen peroxide, and ozone[26] activate the AhR. Involvement of AhR and AhR-regulated genes has also been suggested as one of the effects caused by metals in various tissues, particularly toxic heavy metals[26]. Increased expression of AhR ...
The herbal infusions were cytotoxic to human ovary cancer SKOV-3 and PEO1 cells; this cytotoxicity was compromised by catalase added to the growth medium, demonstrating the contribution of H2O2 to the cytotoxic action of herbal extracts. Keywords: hydrogen peroxide; Xylenol Orange; catalase; ...
4-Hydroxy isoxazolidines were prepared by stereospecific oxidation of the corresponding dioxaborolane by treatment with hydrogen peroxide in THF in the presence of a phosphate buffer (Scheme 78) <1997TL6665>. Sign in to download full-size image Scheme 78. A 4-silyl-substituted isoxazolidi...