There is increasing experimental data that some types of normal﹑ressure glaucoma may involve immune mechanisms directed at self゛ntigens, such as HSP, but proof of the concept that glaucoma is an autoimmune disease remains to be conclusively demonstrated....
The 60 kDa heat-shock protein (hsp60) is... Raz,Itamar,Elias,... - 《Lancet》 被引量: 589发表: 2001年 Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice. Type 1 diabetes (T1D) is an autoimmune disease that is caused by the destruction of ...
ABX treatment (Fig.1e, f). We further detected an interaction effect between the ABX treatment and sex on area under the curve (AUC) of glucose tolerance test (GTT) (P = 0.003) (Supplementary Data1), indicating that male and female mice responded differently to the depletion of the ...
Our data also showed an up-regulation of a number of chaperones (Hspe1, Hspa1a, and Hspb1). In the study carried out by Colome et al. (27), 2D difference gel electrophoresis (DIGE) and Isotope coded protein labeling (ICPL) were used to analyze the effect of AIRE on the cellular ...
Immune checkpoint inhibitors (CPIs) are a relatively newly licenced cancer treatment, which make a once previously untreatable disease now amenable to a potential cure. Combination regimens of anti-CTLA4 and anti-PD-1 show enhanced efficacy but are prone
HSP is the most common vasculitis in childhood and has an excellent prognosis. 152 Compare the common clinical presentations and laboratory findings of MPA, WG, CSS, CV, and HSP See Table 10-10. 153 What is BD? A systemic vasculitic disorder of unknown etiology, characterized by relapsing ...
NephroticSyndromeisanaccumulationofsymptomsandsignsandischaracterizedbyproteinuria,hypoproteinemia,edema,andhyperlipidemia.肾病综合征是由于肾小球滤过膜对血浆蛋白通透性增高，大量白蛋白自尿中丢失，引起一系列病理生理改变的一个临床综合征。本病的特点是大量蛋白尿，低白蛋白血症、严重水肿，高脂血症和高凝状态。N...
HSP990 cell line The 2021 observed rate, encompassing a range of 230-309 (95% confidence interval) and amounting to 267, showed a considerable and statistically significant (p = .010) increase over the anticipated rate of 195, with a 95% confidence interval spanning from 176 to 214.An ...
6c and Supplementary Table 1), indicating that cluster 15 represents neuronal APOE4-promoted disease-associated oligodendrocytes (nE4-DAOs). DE gene analysis revealed that cells in oligodendrocyte cluster 15 exhibited drastically upregulated expression of Hspa8, Hsp90aa1, Hsp90ab1, Calm1, Calm2, ...
that CD4 + T lymphocytes specific for HspB5 were found both in mice with experimental autoimmune encephalomyelitis (EAE) and MS *Division of Immunology an... S Sotgiu,M Pugliatti,S Contu,... - 《European Journal of Neurology》 被引量: 6发表: 2015年 Central nervous system recruitment of ...