Background/Aim: The CRP-albumin-lymphocyte (CALLY) index is a promising biomarker. We clarified the clinical impact of the CALLY index in gastric cancer patients who received curative treatment. Patients and Methods: Consecutive patients who underwent curative resection for gastric cancer at Yokohama ...
These high CRP levels have never been observed in any other infectious viral disease [16]. Clinical studies of 5700 hospitalized patients revealed that the most common comorbidities were hypertension (56.6%), obesity (41.7%), and diabetes (33.8%) [17]. SARS-CoV-2 is a sarbecovirus with an...
The COVID-19 pandemic generated a massive amount of clinical data, which potentially hold yet undiscovered answers related to COVID-19 morbidity, mortality
Annual CAC score progression was 29.7% by statin monotherapy and 14.3% following the addition of the PCSK9 inhibitor to statin therapy. The annual rate of CAC with the combination therapy with a PCSK9 inhibitor and a statin is lower than that with statin monotherapy. CAC may be prevented ...
Prostate cancer (PC) represents a global health issue. Treatment for locally advanced and metastatic PC remains unsatisfactory. The androgen receptor (AR) has been validated in having a key role in both naïve and castrate-resistant PC (CRPC). However, the significance of other signalling pathwa...
Within days to weeks after birth, they had repeated episodes of systemic inflammation with diarrhea and elevated serum C-reactive protein (CRP; Figure 1B) and white blood cell (WBC) and neutrophil count (Figure 1C) without evidence of infection. All three eventually developed relapsing nodular ...
Extensive research on the tumor microenvironment, enriched by a high concentration of tumor-infiltrating lymphocytes, has highlighted their pivotal role in the survival of cancer patients. In contrast to their non-infiltrating counterparts, tumor-infiltrating lymphocytes (TILs) are a notable population of...
Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX-Bevacizumab Drug Treatment Regimen Host immunity controls the development of colorectal cancer, and chemotherapy used to treat colorectal cancer is likely to recruit the host immune system...
However, when deprived of androgen stimulation, hormone naive prostate cancer (HNPC) cells gain the capability to survive and thrive by upregulating oncogenic pathways. After 18–24 months, MAB begins to fail, with the cancer evolving into castrate-resistant prostate cancer (CRPC). Castrate-...
Our in vitro study of the consequences of each mutation on IMPDH2's structure and function demonstrates that every mutation is a gain-of-function, thereby preventing IMPDH2 from undergoing allosteric regulation. High-resolution structures of one variant are reported, along with a hypothesized ...