IntroductionPost-operative colorectal cancer resections are high risk due to associated morbidity and mortality (30% and 6.7%, respectively). Anastomosis leak has been associated to a negative impact upon survival, independent of tumour staging. C-Reactive Protein (CRP; 125鈥 190 mg/L) has a ...
TC / HDL-C and TYG. In addition, the results of this study show that CRP and LHR can predict the survival of cancer patients. Both high CRP and high LHR predicted poor OS. The mortality
Elevated CRP levels indicate poor progression-free and overall survival on cancer patients treated with PD-1 inhibitors. ESMO Open. 2019;4(4):e000531. 96. Shoji F, Takeoka H, Kozuma Y, Toyokawa G, Yamazaki K, Ichiki M, et al. Pretreatment prognostic nutritional index as a novel ...
The IL-6High/IL-1βLow group showed a higher CRP level than the IL-6Low/IL-1βLow group (P=0.001). Table 5 CRP level according to serum levels of IL-6 and IL-1β in patients with gemcitabine monotherapy for advanced pancreatic cancer Full size table...
IL18 demonstrated diagnostic value and was significantly correlated with acute-phase markers namely CRP, fibrinogen, and fer- ritin. Altered levels of IL18 and miR-451a could distinguish FMF patients in the attack period from the ones in remission. miR-26a-5p, miR-146a-5p, and miR-155–2...
Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of survivin studies in the cancer field. Many studie
Androgen deprivation therapy (ADT) is the standard of care for men with metastatic hormone-sensitive prostate cancer (HSPC) and a potential treatment option in those with prostate-specific antigen relapse after local therapy. Based on promising biological and preclinical data, several clinical trials ...
In CRPC cell lines, SP2509 bound a pocket distinct from that bound by LSD1 catalytic inhibitors and disrupted interaction of LSD1 with ZNF217, another member of the COREST complex, to reverse castrate resistance [49]. In breast cancer cell lines [30], SP2509 disrupted TBX2-LSD1 ...
H3K27me3-rich regions component removal at interaction anchors by CRISPR leads to upregulation of interacting target genes, altered H3K27me3 and H3K27ac levels at interacting regions, and altered chromatin interactions. Chromatin interactions did not change at regions with high H3K27me3, but ...
Collectively, these results indicate that serum levels of VEGF and IL-6, but not serum PlGF or serum sFlt-1, could represent synovial proliferation and hypervascularity on US and reflect the systemic inflammatory status of RA assessed by TJC, SJC, ESR, CRP, and DAS28. ...