8.6 Renal Impairment No dosage adjustment is necessary for patients with mild or moderate renal impairment (creatinine clearance greater than or equal to 30 mL/min) [see Clinical Pharmacology (12.3)]. In patients with severe renal impairment (creatinine clearance less than 30 mL/min) or end-...
Additionally, maintaining an ideal cardiovascular health (CVH) may potentially decrease the risk of HUA and gout. However, further studies are necessary to provide robust evidence for establishing causality.Data availability This study is a secondary analysis based on a publicly available database and ...
Thus, the significance of the TyG index for predicting CAC progression is still uncertain in individuals with heavy calcification at baseline. Further prospective studies with a large sample size are necessary to confirm this issue. The mechanism underlying the relationship of the TyG index with ...
Surprisingly, we did not observe an association between the APOL1 genotype and proteinuria among women with a history of clinical AIDS. Although this suggests that APOL1 risk alleles may not be necessary for the onset of renal disease in advanced stages of HIV infection, this subgroup was small...
However, the protective properties of Tug1 were mitigated when Pgc1α was knocked down in podocytes in induced db/db; TugPodTg; Pgc1αPod-f/f mice, suggesting that PGC1α is necessary for the modulatory effects of Tug1 on mitochondrial morphology. Download: Download high-res image (1MB) ...
Blood pres- sure of the right arm was measured using an automatic manometer after resting for at least more than 5 min. All blood samples including total cholesterol, triglyc- eride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), creatinine, ...
The serum was removed and kept at -20 °C until ready for use. Biochemical analyses were conducted with an Olympus AU5400 fully auto- matic biochemical analyzer (Olympus Corp, Tokyo, Japan). The levels of serum urea (UREA), creatinine (CRTN), alanine aminotransferase (ALT), total ...
Alanine aminotransferase; ALP: Alanine phosphotransferase; γ-GT: Gamma-glutamyl transferase; LD: Lactate dehydrogenase; Ch-E: Cholinesterase; AMY: Amylase; CK: Creatine kinase; CK-MB: CK myocardial band; UN: Urea nitrogen; CRE: Creatinine; UA: Urinalysis; eG...
U cAMP/creat (nmol/mg) 3.00±0.57 1.73±0.22a 2.76±0.36 1.56±0.31a Body weight (kg) 70.6±4.3 69.7±4.3a 68.3±3.4 67.5±3.4a Abbreviations: ADPKD, autosomal dominant polycystic kidney disease; AVP, arginine vasopressin; cAMP, cyclic adenosine monophosphate; creat, creatinine; CTRL, control...
Flavan-3-ols are a group of bioactive compounds that have been shown to improve vascular function in intervention studies. They are therefore of great interest for the development of dietary recommendation for the prevention of cardio-vascular diseases.