Factor V Leiden (FVL) mutation is the most common genetic defect that predisposes to thrombosis. The reconstruction of hepatic artery with arterial graft is a documented risk factor for HAT. However, the relationship among \\{FVL\\} mutation, arterial graft, and \\{HAT\\} remains to be ...
In addition to the genetic variants currently used in clinical assessment of hereditary thrombophilia (e.g., Factor V Leiden, prothrombin mutation) there are other more recently discovered common gene variants that contribute to VTE risk15,16,17. However, even when these are also incorporated into...
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Genetic Hypofibrinolysis in Complicated Pregnancies Objective: To assess the hypofibrinolytic 4G/4G mutation of the plasminogen activator inhibitor (PAI-1) gene as a possible factor contributing to severe pr... CJ Glueck,MJ Kupferminc,RN Fontaine,... - 《Obstetrics & Gynecology》 被引量: 367发...
G. et al. A candidate genetic risk factor for vascular disease—a common mutation in methylenetetrahydrofolate reductase. Nat. Genet. 10, 111–113 (1995). 2 de Bree, A., Verschuren, W. M., Bjørke-Monsen, A. L., van der Put, N. M., Heil, S. G., Trijbels, F. J. et ...
Oral contraceptives and factor V Leiden mutation each increase the risk of venous thrombosis; their separate and joint effects can be calculated from the 2 by 4 table (see example 1 for item 17) where the odds ratio of 1 denotes the baseline of women without Factor V Leiden who do not ...
where Σ foot process is the total number of foot processes counted in each picture, Σ GBM length is the total GBM length measured in each picture, and the correction factor of serves to correct for presumed random variation in the angle of section relative to the long axis of the podocyte...
fitted linear models to test for an association between each autosomal SNPyjand each of 10,286X-chromosomal CpGsxiindividually, correcting for known covariatesM(cell counts, cohort, age, technical batches—e.g., sample plate and array position) and unknown confounding by including latent factorsU...
(1) F5L: a set of 227 French–Canadian individuals belonging to five extended families (each ascertained through a single proband with idiopathic VT and carrying the factor V Leiden mutation55. These whole-blood samples were profiled on the HumanMethylation450 array and genotyped on the Human...
(Phosphoinositide-3-Kinase Regulatory Subunit 1; degree = 18), a major astrocytic hub gene and a subunit of PI3K that has been identified as a novel genetic variant in the progression of AD [46]. While the implications of the enrichment of insulin and PI3K–AKT/Rho GTPase signalling ...