to parental cell lines. To further characterise the resistance mechanism in our cells microRNA prediction software identified miR-221 as a negative regulator of EGFR expression. miR-221 was up-regulated in our resistant cell lines, and this up-regulation led to a significant reduction in EGFR exp...
Renal function was evaluated by estimated glomerular filtration rate (eGFR) within 3 days prior to the CMR examination. Only patients with eGFR >30 mL/min/1.73 m2 could receive CMR examination. Patients with hypertension were carefully reviewed his/her medical history and CMR images (n ...
gGFR measured by99mTc‐DTPA renal dynamic imaging is significantly lower than eGFR estimated by the CKD‐EPI equation, which indicates that isotope renogram cannot accurately evaluate the GFR of HSK patients. GFR determined by isotope renal dynamic imaging was compared to eGFR (CKD‐EPI) in 19 ...
Eliminating genes are known as another mechanism of CAR T cell-selective exhaustion. To induce the CAR T cell death, CD20 or EGFR identified as cell surface antigens can be used in CAR structure. Then, the infusion of CD20 (rituximab) or EGFR (cetuximab) mAbs trigger the CAR T cell deat...
in 10 cell types.DStacked diagram of cell distribution in normal and tumor tissues.EBar plot showing the number of fibroblasts in normal and tumor tissues.FQuantification of CAFs abundance in LUAD using the EPIC algorithm, and analysis of the prognostic value of CAFs using the K-M curve ...
Furthermore, no data on genetic driver mutations such as the epidermal growth factor receptor (EGFR) and the echinoderm microtubule-associated protein-like-anaplastic lymphoma kinase (EMLA-ALK) were available in NSCLC patients, and therefore we were unable to evaluate if the mutation-positive ...
It is clear that the receptor tyrosine kinase EGFR has an important role in the pathogenesis of HNSCCs as its overexpression was observed even in the early stages of tumorigenesis. Nevertheless, it seems that the expression of the EGFR protein is not appropriate for predicting the effectiveness of...
aHuman actions, not live 人的行动,不居住[translate] a对不起我没有听明白你的意思 正在翻译,请等待...[translate] aEGFR is expressed on the cell surface of normal cells and cancer cells. EGFR 关于正常的细胞和癌细胞的细胞表面被表达。[translate]...
Suboptimal rise in awakening-induced cortisol is an accurate marker of cortisol insufficiency in patients with normal renal function (eGFR >60 mL/min). 来自 学术范 喜欢 0 阅读量: 5 作者:R Ramachandran,J Alaghband-Zadeh,A Sankaralingam,SA Khan,M Tavabie,C Fernyhough,M Sabry,N Maghsoodi,B...
Taken together, we provide evidence that the plant flavonoid fisetin can induce apoptosis and suppress the growth of colon cancer cells by inhibition of COX2- and Wnt/EGFR/NF-B-signaling pathways. We suggest that fisetin could be a useful agent for prevention and treatment of colon cancer. ...