An average eGFR varies by age, but in younger adults who are considered healthy, a range of 80-120mL/min/1.73 m2is generally normal. GFR decreases as you get older, but a reduced GFR can cause similar issues in older adults as in those who are younger. Adecrease in GFR could also b...
Cancer stem cells and tumor transdifferentiation: implications for novel therapeutic strategies. Am. J. Stem Cells 2, 52–61 (2013). CAS PubMed PubMed Central Google Scholar Sequist, L. et al. Genotypic and histolgical evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. ...
Hair changes during EGFR treatment may: Make the eyelashes grow very fast and become very long and bother your eyes Cause fast growth to eyebrows Cause hair on the scalp to become curly, fine, or brittle Start a few weeks to months after starting treatment and go away after treatment is ...
PCR (Protein Creatinine Ratio) is a test that gives information about how the kidneys are working. It measures the levels of protein and creatinine in urine. This test is ordered if people have signs of preeclampsia and at a routine physical examination to screen for proteinuria. Normal urine ...
No data are available, however, on the performance of these formulae in Arab individuals.Plasma creatinine samples were obtained from 90 consecutive normal Arab kidney donors for the estimation of GFR (eGFR) using the simplified MDRD and CG formulae. The GFR was measured in these donors with ...
In particular, cetuximab (chimeric IgG1 monoclonal antibody) binds epidermal growth factor (EGFR) and is used in RAS wild type metastatic CRC. It has been suggested that cetuximab, in addition to direct inhibition of EGFR, may act via ADCC. ADCC allows the antitumor innate immune response but...
Secondarily, a high tumor proportion score (TPS) equal to or greater than 25% on FFPE by IHC demonstrated its prognostic value as a predictor of clinical outcome in virtue of its association with smoking history, diagnostic molecular analysis of EGFR, tumor size and nodal status in these ...
M. et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 1, 269–277 (2002). Article CAS PubMed Google Scholar Zhu, H. et al. Oncogenic EGFR signaling ...
Metabolic reprogramming is a pivotal biological process in which cellular metabolic patterns change to meet the energy demands of increased cell growth and proliferation. In this review, we explore metabolic reprogramming and its impact on fibrotic disea
the molecular mechanism that regulates host-microbiota homeostasis in normal and ASD states is not known. The analyses needed to address this knowledge gap are challenging to perform in humans and rodents due to the high costs and tedious process of comparing the microbiomes of multiple genetic mod...