In Ulcerative Colitis (UC) CRP is considered a less reliable biomarker of inflammation and disease activity. However, elevated CRP levels have been associated with an increased risk of colorectal cancer and colectomy in UC. Therefore, in UC clinical trials, data analysis has been mostly focused ...
Is CRP elevated in ankylosing spondylitis?Ankylosing SpondylitisAnkylosing spondylitis is a form of arthritis that leads to the development of lower back pain. Physical exercise is the typical remedy employed in resolving pain among individuals with this condition. Risk factors for ankylosing spondylitis ...
A high level of CRP in the blood is amarker of inflammation. It can be caused by a wide variety of conditions, from infection to cancer. High CRP levels can also indicate that there's inflammation in the arteries of the heart, which can mean a higher risk of heart attack. Is high CR...
Like NFIB, CARM1 is often overexpressed in human cancers, including lung cancer1,29. Furthermore, in a mouse model of overexpression, elevated CARM1 levels in Keratin 5 (K5) expressing tissues (skin and the mammary gland) present with a high incidence of spontaneous tumors30. These findings ...
Lineage plasticity is a hallmark of cancer progression that impacts therapy outcomes, yet the mechanisms mediating this process remain unclear. Here, we introduce a versatile in vivo platform to interrogate neuroendocrine lineage transformation throughou
Prostate cancer (PC) represents a global health issue. Treatment for locally advanced and metastatic PC remains unsatisfactory. The androgen receptor (AR) has been validated in having a key role in both naïve and castrate-resistant PC (CRPC). However, the significance of other signalling pathwa...
There was a positive relation between elevated markers of systemic inflammation and markers of nutritional depletion. Serum CRP and sTNF-r concentrations were positively correlated significantly with weight loss, a finding in keeping with previous studies on human cancer subjects (6, 7). Serum cytokin...
as a mitotic kinase, however, recent findings have uncovered an equally important role of interphasic AURKA in normal cells. In contrast, in cancer tissues, AURKA is overexpressed in a cell-cycle-independent manner and is mislocalized in the cytoplasm and/or nucleus depending upon the cancer. ...
Circular RNAs (circRNAs) have been shown to be involved in tumorigenesis and progression. However, the role of circGLIS3 (hsa_circ_0002874) in prostate cancer (PCa) has yet not been reported. Candidate circRNA were determined through comprehensive analys
CRP binds to the surface of damaged human cells. Surface-bound CRP recruits the complement initiator C1q, which activates the classical complement pathway[6], and we have previously shown that expression of C1q is elevated in glioblastoma tissue as compared to non-tumor brain tissue[15]. CRP ...