For the H2RA cohort (n = 162,189), reports where ranitidine, famotidine, cimetidine, and nizatidine were used, excluding concurrent PPI use. The cohorts were further narrowed down to “monotherapy” reports. This assignment was defined when a submitted report contained a single PPI or a ...
cimetidine in 1976 and the subsequent launch of omeprazole in 1988,their use has slowly declined.First line treatment for patients with symptomatic gastritis after removal of potential causative factors is likely to be a proton pump inhibitor in 2019.This is despite the fact that there is some ...
Quadruple therapy (proton pump inhibitor, tetracycline, metronidazole and a bismuth salt) is a very effective regimen even in areas of high prevalence of antibiotic resistance, and may be an alternative first-line treatment. How effective is bismuth quadruple therapy for H pylori? pylori (susceptible...
Additionally, ketoconazole interacts with numerous drugs, typically increasing other drugs' blood levels and causing toxicity. H2 blockers, such as cimetidine (Tagamet), ranitidine (Zantac), or famotidine (Pepcid) decrease ketoconazole's effectiveness. Proton pump inhibitors, such as omeprazole (...
The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministrat... As a direct-acting inhibitor of CYP2C19 in vitro, lansoprazole is more potent than omeprazole and other proton pump inhibitors (PPIs), but ...
Which of the following drugs works by irreversibly inhibiting the H+/K+-ATPase pump in order to reduce acid secretion? a. Aluminum hydroxide b. Cimetidine c. Omeprazole d. Metoclopramide Which pharmacological factor (potency or efficacy) is the KD of a drug-receptor interaction more closely rela...
患者，女，21岁，学生。10d前出现发热、腰痛，遂来院就诊。急性面容，体温39°C、脉搏140次/min、血压105/70mmHg，脾肿大，心脏听诊有杂音，全身皮肤有多处出血斑点，疑为亚急性细菌性心内膜炎。若该患者还需查心肌酶、血沉，则下列说法错误的是