Proton pump inhibitors (PPIs) belong to a family of drugs that bind to the H+/K+ -ATPases in the gastric epithelial cells that secrete hydrochloric acid inhibiting acid release. From: Medicinal Chemistry of Anticancer Drugs (Third Edition), 2023 ...
Journal of Enzyme Inhibition & Medicinal ChemistryLugini L, Federici C, Borghi M, Azzarito T, Marino ML, Cesolini A, et al. Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect, J Enzyme Inhib Med Chem. 2015; 28: 1-8....
These include new drug formulations, novel proton pump inhibitors (PPIs) as well as potassium-competitive acid blockers (P-CABs), which have already reached clinical testing. Some others (like NO-releasing antisecretory compounds) are still in preclinical development and require proof of concept in...
Current Medicinal ChemistryInteractions Between Clopidogrel and Proton Pump Inhibitors: A Review of Evidence. C. Munoz-Esparza,E. Jover,D. Hernandez-Romero. Current Medicinal Chemistry . 2011Munoz-Esparza C, Jover E, Hernandez-Romero D, Saura D, Valdes M, Lip GY, et al. Interactions between ...
In conclusion, we demonstrate that gastric proton-pump inhibitors can be used as scaffold in drug-development to design better anti-parasitic molecules. Our data also offer a molecular mechanism of reaction in which the kind of adducts generated, together with the covalent bond that link to them...
Racemic proton pump inhibitors (PPIs) have been developed into pure enantiomers given superior pharmacokinetic profiles. However, after doses of single enantiomer PPIs, different degrees of chiral inversion were observed. We investigated the relationship between chiral inversion and reductive metabolism of ...
S-omeprazole and R-rabeprazole are important proton pump inhibitors (PPIs) used for treating peptic disorders. They can be biosynthesized from the corresponding sulfide catalyzed by Baeyer-Villiger monooxygenases (BVMOs). During the development of BVMOs for target sulfoxide preparation, stereoselectivity...
Prodrugs of proton pump inhibitors of Formulas 1 through 4, (I-IV), where the symbols are as defined in the specification, and the R group includes at least one acidic group or its pharmaceutically acceptable salt, have improved aqueous ... ME Garst,S George,SJ Moo - WO 被引量: 12发表...
It was shown that the activities of the V/H+-PPase inhibitors can be predicted to within about a factor or two. In addition, the CoMFA results emphasize the overwhelming importance if electrostatic interactions between the biophosphonates and the V/H+-PPase....
In this study, Proton pump inhibitors (PPIs) were identified as potential kinase inhibitors based on their structural similarity to known inhibitors of five protein kinases, namely, CaMKII delta, FLT3, FGFR1, ALK, and TYK2. The in vitro inhibitory effects of the five FDA-approved PPIs, ...