CimetidinePhenytoinCimetidineCYP2C9CYPCytochromeP450This case discusses a pharmacokinetic interaction between cimetidine and phenytoin. Phenytoin is a cytochrome P450 2C9 and 2C19 substrate and cimetidine is a cytochrome P450 2C9 and 2C19 inhibitor. Coadministration results in phenytoin toxicity....
Avoid co-administration of LUPKYNIS with strong or moderate CYP3A4 inducers. 7.2 Effect of LUPKYNIS on Other Drugs Certain P-gp Substrates Voclosporin is a P-gp inhibitor. Co-administration of voclosporin increases exposure of P-gp substrates [see Clinical Pharmacology( 12.3)] , which may...
10 Glucocorticoid (systemic): Dexamethasone (more than a single-dose treatment) H2-receptor antagonists: Famotidine Cimetidine Nizatidine Ranitidine Herbal product: St John's wort (Hypericum perforatum) Macrolide or ketolide antibiotics: Clarithromycin Erythromycin Telithromycin Medications containing polyvalent ...
Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in f... (a nonspecific inhibitor of CYP isozymes), sulfaphenazole, cimetidine, quinine hydrochloride and troleandomycin, inhibitors of CYP2C6,...
May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside (PubMed:15644426). May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the ...
In the time of James Black, often small series of hundreds of compounds were synthesized, tested and optimized in animals empirically (leading to drugs such as cimetidine and propranolol [37]). But with the advent of molecular biology, an increasing amount of effort has been made to understand...
Which of the following SSRIs is a potent inhibitor of both CYP_2D_6 and CYP_2B_6? A) Paroxetine. B) Citalopram. C) Sertraline. D) Fluvoxamine. Considering the given erlotinib and terbinafine. Erlotinib, sold under the trade name Tarceva, was introduced in 2004 for the treatme...
astemizole. busulfan. cimetidine. disulfiram. lithium. medications that inhibit cytochrome p450 enzymes (CYP2C9 and possibly others), such as phenytoin or phenobarbital. Is bismuth safe for humans? Health effects of bismuth Bismuth and its salts can cause kidney damage, although the degree of su...
Which of the following drugs is a direct renin inhibitor? A) Aliskiren. B) Clonidine. C) Methyldopa. D) Minoxidil. Which of the following drugs works by irreversibly inhibiting the H+/K+-ATPase pump in order to reduce acid secreti...
metabolized by the potent hepatic and intestinal cytochrome P450 (CYP3A4); for this reason, EVG must be pharmacokinetically boosted with a CYP3A4 inhibitor. Cobicistat (COBI) is currently FDA approved for this purpose in a combination “quad” pill: EVG/COBI/tenofovir (TDF)/emtricitabine (FTC...