10 Glucocorticoid (systemic): Dexamethasone (more than a single-dose treatment) H2-receptor antagonists: Famotidine Cimetidine Nizatidine Ranitidine Herbal product: St John's wort (Hypericum perforatum) Macrolide or ketolide antibiotics: Clarithromycin Erythromycin Telithromycin Medications containing polyvalent ...
Avoid co-administration of LUPKYNIS with strong or moderate CYP3A4 inducers. 7.2 Effect of LUPKYNIS on Other Drugs Certain P-gp Substrates Voclosporin is a P-gp inhibitor. Co-administration of voclosporin increases exposure of P-gp substrates [see Clinical Pharmacology( 12.3)] , which may...
CimetidinePhenytoinCimetidineCYP2C9CYPCytochromeP450This case discusses a pharmacokinetic interaction between cimetidine and phenytoin. Phenytoin is a cytochrome P450 2C9 and 2C19 substrate and cimetidine is a cytochrome P450 2C9 and 2C19 inhibitor. Coadministration results in phenytoin toxicity....
Cases of pure red cell aplasia (PRCA) have been reported in patients treated with another calcineurin-inhibitor immunosuppressant. All of these patients reported risk factors for PRCA such as parvovirus B19 infection, underlying disease, or concomitant medications associated with PRCA. A mechanism for ...
EVG is unique among this drug class as it is primarily metabolized by the potent hepatic and intestinal cytochrome P450 (CYP3A4); for this reason, EVG must be pharmacokinetically boosted with a CYP3A4 inhibitor. Cobicistat (COBI) is currently FDA approved for this purpose in a combination “...
(1996) reported that pretreatment of rats with cimetidine potentiated the acute toxicity of diazinon as a result of reducing diazinon total body clearance. Likewise, coadministration of diazinon with cocaine significantly increased the concentration of cocaine and norcocaine in the blood and tissues of...
astemizole. busulfan. cimetidine. disulfiram. lithium. medications that inhibit cytochrome p450 enzymes (CYP2C9 and possibly others), such as phenytoin or phenobarbital. Is bismuth safe for humans? Health effects of bismuth Bismuth and its salts can cause kidney damage, although the degree of su...
Cimetidine and ranitidine, both \\{CYP\\} inhibitors as well as \\{H2\\} blockers, caused relaxation of the term and preterm mouse DA. \\{CYP\\} enzymes that are inhibited by cimetidine were expressed in \\{DA\\} subendothelial smooth muscle. The selective \\{CYP3A\\} inhibitor ...
For example, it can transport small molecules such as cimetidine (MW 252) and small peptides such as N-acetyl-leucyl-leucyl-norleucinal (MW 383), as well as large molecules such as cyclosporine A (MW 1203) and gramicidin D (MV 1882) [25]. SLCO1B1 also transports a wide range of ...