Cholesterol: Phospholipid Ratio is Increased in the Plasma Membrane of Platelets from Patients with Primary HypertensionAn abstract is unavailable. This article is available as a PDF only.doi:10.1042/cs074049PBenjaminGrahamJ. MRobinsonB. FWilson...
Given that cholesterol is synthesized within the cell, it is unclear why most of the zymosterol is in the plasma membrane. The pathway of cholesterol biosynthesis may compel zymosterol to flux through the plasma membrane. Alternatively, plasma membrane zymosterol may represent a separate pool, in...
We have examined the role of membrane order (L o)/ disorder (L d) in antigen specific CD4 + T cell activation and clonal expansion by first creating membrane disorder, and then reconstituting membrane order by inserting cholesterol into the disordered plasma membrane. Significant revival of ...
Despite the importance of the role of cholesterol in the mammalian plasma membrane (1), its distribution between the exoplasmic and cytoplasmic leaves is unknown. This is not because there have been no attempts to measure it. To the contrary, it has been measured many times, but the variation...
These results suggest that FC generated by the hydrolysis of cytoplasmic CE is transported through acidic vesicles to the plasma membrane, and accumulation of FC in this pool triggers cell death by necrosis and apoptosis. 展开 关键词: Cytotoxic cholesterol Hydrolysis Cytoplasmic cholesteryl ester ...
The present study investigated the cholesterol-lowering activity of gingerol- and shogaol-enriched ginger extract (GSE). Thirty hamsters were divided into three groups and fed the control diet or one of the two experimental diets containing 0.5 and 1.0% GSE. Plasma total cholesterol, liver cholester...
Fig. 1: PI(4,5)P2is enriched in the plasma membrane of epithelial cells. aImmunofluorescence detection of PI(4,5)P2in skin sections of newborn mice. The dotted line denotes the border between the epidermis and the dermis. Results shown are representative of two independent experiments.b,cIm...
The transport of newly synthesized cholesterol from its site of synthesis, the endoplasmic reticulum, to the plasma membrane was studied in CaCo-2 cells. The appearance of newly synthesized cholesterol on the cell surface was rapid. By 30 min, 50% of the total labeled cholesterol was observed ...
Recent data highlight that lipid metabolism is perturbed in brains and livers of MECP2-null male mice. In addition, altered plasma lipid profile in RTT patients has been observed. Thus, the aim of the work is to investigate the protein network involved in cholesterol homeostasis maintenance on...
A. Esterified cholesterol is highly localized to Bruch’s membrane, as revealed by lipid histochemistry in wholemounts of human choroid. J. Histochem. Cytochem. 57, 731–739 (2009). Article CAS PubMed PubMed Central Google Scholar Chuang, J. Z., Hsu, Y. C. & Sung, C. H. ...