The scientific study of matter's characteristics and behaviour is known as chemistry.andare different from the normal vocabulary. It is a branch of natural science that examines the building blocks of matter, including the atoms, molecules, and ions that make up compounds and their composition, s...
The position of chlorine incorporation was elucidated by 1H-NMR (D2O, 500.13 MHz). 2-H was observed at δ 7.35 (s), and 4-H at δ 7.62 (d) was found to be coupled with 6-H (dd) at δ 7.12 (J = 2.0 Hz). 6-H was also found to be coupled with 7-H at δ 7.35 (d, J...
Elemental chlorine exists as the diatomic molecule Cl2 in the gas, liquid, and solid states; the major difference between them lies in the degree of organization. In the gas the molecules move about randomly, whereas in the solid they are constrained to locations in a 3-dimensional lattice. ...
(150 ml) was added dropwise. The solution was then stirred for 2 h at ambient temperature. The resulting precipitate was collected by filtration and washed with ice water. The solid was dried to give product90d(38 g, 71% yield).1H NMR (400 MHz, CDCl3)δ(ppm) 7.01 (s, 1H...
In order to examine the effects of the chlorine atoms in the close analogue chlorotonil, the scientists chlorinated anthracimycin. This chlorine-containing analogue proved to be only about half as effective against B. anthracis. However, its activity against a number of Gram-negative pathogens inc...
2.The compound of claim 1, wherein each halogen is selected from fluorine or chlorine. 3.The compound of claim 1, whereinR12is:(a) aliphatic; heteroalkyl; heterocycle; aryl; heteroaryl;(b) aliphatic substituted with an oxy, acetyl, aliphatic, heteroalkyl, or alkylsulfonyl;(c) heteroalkyl...
20.A process according to claim 15, wherein X represents, identically or differently, one at least of the groups chosen from a chlorine atom and a group of formula —OR5in which R5represents a C1-C4alkyl radical. 21.A process according to claim 15, wherein n is a number of less than...
As used herein, the term “halogen” means a fluorine, chlorine, bromine or iodine radical, preferably a fluorine or chlorine radical. As used herein the term “prodrug” means any pharmaceutically acceptable prodrug of the compound of formula (I) which is metabolised in vivo to a compound ...
The active ingredients are employed in a purity of from 90% to 100%, preferably 95% to 100% (according to NMR spectrum). The compounds according to the invention can, for example, be formulated as follows: I 20 parts by weight of the active compound composition in question are dissolved...
5′-trifluoroacetophenone (1.0 g, 5.7 mmol) to produce 0.44 g (48% yield) of the product as a white solid: IR νmax (Nujol/cm−1)1642, 1513, 1461, 1377, 1336, 1202, 1055 and 848; NMR δH (400 MHz, CDCl3) 2.55 (3H, s), 7.19 (1H, dd, J 4, 6 Hz) and 7.39 (1H...