The histone-like nucleoid structuring (H-NS) protein is a DNA binding factor, found in gammaproteobacteria, with functional equivalents in diverse microbes. Universally, such proteins are understood to silence transcription of horizontally acquired genes
pseudomallei samples from the northeast Thailand collection were cultured on Ashdown, selective agar plates and confirmed the species using latex agglutination test and matrix-laser absorption ionisation mass spectrometry (MALDI-TOF MS). A single colony from Ashdown agar plate was subjected to culture ...
Darapladib was originally developed as a selective inhibitor of extracellular lipoprotein-associated PLA2 (Lp-PLA2) (Blackie et al., 2003). However, Lp-PLA2 is absent in RBCs and is also not internalized by P. falciparum-infected RBCs from ...
Is Salmonella enterica arrangement called Bacillus or flagella? What is the most antibiotic resistant bacteria? Which pathogen (Staphylococcus epidermidis or E. coli) is able to grow on Blood Agar plate and why? Is this type of agar serving as differential, as selective, or as both? Explain wh...
Importantly, like Kuramochi, RMG1 showed differential sensitivity to PARGi and PARPi. However, while OVMANA were more sensitive to PARGi than PARPi, the distinction was less clear-cut. These observations indicate that PARG inhibitors may open up new opportunities to treat ovarian cancers. However...
Therefore, specific inhibition of tumor cell migration via CB1-R engagement might be a selective tool to prevent metastasis formation without depreciatory effects on the immune system of cancer patients. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells gut.bmj....
to calcium and sodium influx/potassium efflux (29, 30), opening of the mitochondrial permeability transition pore (46), interaction with APOL3 (47), differential localization to lipid droplets (48), activation of the inflammasome (49), and/or differences in potassium flux between variants (50)...
We used tDNA fragments with a selective antibiotic resistance provided via a heterologous gene cassette (HGC) or a single nucleotide polymorphism (SNP). We performed the survival assay with stress added 10 min after CSP, and exogenous transforming DNA (tDNA) was added at the same time as ...
To test the metabolic functions of BMAT in vivo we first used18F-FDG PET/CT in mice to determine if, like WAT, BMAT is insulin-responsive. As expected, insulin decreased blood glucose (Fig.3a) and increased18F-FDG uptake in the heart, iWAT, gWAT and skeletal muscle (Fig.3b, c, e)....
Targeted analyses of AD plasma such as Aβ42, Aβ40, various pTau species, GFAP and neurofilament light chain (NEFL) have provided highly informative blood-based biomarkers that clearly reflect underlying pathological processes in the brain [66]. However, broader integration of AD plasma proteome...