Typically, antibiotic resistance leads to reduced sensitivity, yet in some cases the evolution of drug resistance can lead to enhanced sensitivity to unrelated drugs. This phenomenon of collateral sensitivity is largely unexplored in M. tuberculosis but has the potential to identify alternative ...
Antibiotic resistance represents a growing health crisis that necessitates the immediate discovery of novel treatment strategies. One such strategy is the identification of collateral sensitivities, wherein evolution under a first drug induces susceptibility to a second. Here, we report that sequential ...
An understanding of fitness costs and compensatory evolution should allow us to make better quantitative predictions about the rate and trajectory of the evolution of resistance to new and old drugs. Abstract Most antibiotic resistance mechanisms are associated with a fitness cost that is typically obse...
particularly prevalent. This may be due to surveying bias, as nearly all studies investigating phenotypic resistance checked for resistance to β-lactams and aminoglycosides via either antibiotic resistance assays or targeted PCR of antibiotic resistance genes (Fig.1, bottom right panel; Additional file5...
Quantitative Biology - Populations and Evolution90C2768Q2590C6092B05The antibiotics time machine is an optimization question posed by Mira et al. on the design of antibiotic treatment plans to minimize antibiotic resistance. The problem is a variation of the Markov decision process. These authors ...
“real-time” is required to examine and track pathogen evolution. For example, the Global Influenza Surveillance and Response System, designed to monitor the quickly evolving and recombining influenza virus in a timely manner, has served for over half a century as a global alert mechanism for ...
Davies Origins and evolution of antibiotic resistance Microbiol. Mol. Biol. Rev., 74 (3) (2010), pp. 417-433 View in ScopusGoogle Scholar [2] J. Li, R.L. Nation, J.D. Turnidge, R.W. Milne, K. Coulthard, C.R. Rayner, D.L. Paterson Colistin: the re-emerging antibiotic for ...
Van Baalen - 《Evolution》 被引量: 75发表: 2010年 Against Bifunctional Antibiotics, Resistance Is Futile A research team has created a novel type of antibacterial agent designed to combat the growing problem of antibiotic resistance. The antibiotics are bifunc... BORMAN,STU - 《Chem.eng.news》...
Molecular evolution of beta-lactam-resistant Haemophilus influenzae: 9-year surveillance of penicillin-binding protein 3 mutations in isolates from Japan Antimicrob Agents Chemother, 50 (2006), pp. 2487-2492 View in ScopusGoogle Scholar [7] K. Ubukata, Y. Shibasaki, K. Yamamoto, N. Chiba, K....
(abcA) gene, which is also a part of the ABC transporter family and could potentially play a role in multidrug antibiotic resistance; however, it is also an integral part of cell metabolism [64]. One CDSs was homologous to themrcAgene, which is responsible for the regulation of β-...