Typically, antibiotic resistance leads to reduced sensitivity, yet in some cases the evolution of drug resistance can lead to enhanced sensitivity to unrelated drugs. This phenomenon of collateral sensitivity is largely unexplored in M. tuberculosis but has the potential to identify alternative ...
Different works have explored independently the evolution toward antibiotic resistance and the role of eco-adaptive mutations in the adaptation to a new habitat (as the infected host) of bacterial pathogens. However, knowledge about the connection between both processes is still limited. We address th...
Revealing the genetic changes responsible for antibiotic resistance can be critical for developing novel antibiotic therapies. However, systematic studies correlating genotype to phenotype in the context of antibiotic resistance have been missing. In order to fill in this gap, we evolved 88 isogenic Esch...
Antibiotic resistance is thought to have evolved long before naturally occurring antibiotics and their derivatives were used to treat human disease, but direct evidence for genes that encode resistance has been lacking. Now, an ancient vancomycin-resista
Multicomponent antibiotic resistance is also a suitable model for studying a central biological question: how do adaptations that require acquisition of multiple mutations evolve? The mechanism underlying the evolution of complex resistance mechanisms is not completely elucidated7–11. Our work aims to ...
关键词: antibiotic resistance evolution genomics bioinformatics bacterial pathogens microbiology DOI: 10.1016/S1359-6446(98)01273-2 被引量: 40 年份: 1998 收藏 引用 批量引用 报错 分享 全部来源 求助全文 全文购买 Elsevier dx.doi.org Ingenta ResearchGate EBSCO 查看更多 相似文献 参考文献 引证文献...
Antibiotics and antibiotic resistance: A bitter fight against evolution One of the most terrible consequences of Darwinian evolution is arguably the emergence and spread of antibiotic resistance, which is becoming a serious men... A Rodríguez-Rojas,J Rodríguez-Beltrán,A Couce,... - 《...
Bypass of genetic constraints during mutator evolution to antibiotic resistance Genetic constraints can block many mutational pathways to optimal genotypes in real fitness landscapes, yet the extent to which this can limit evolution re... A Couce,A Rodríguez-Rojas,J Blázquez - 《Proceedings of the...
Antibiotic resistance represents a growing health crisis that necessitates the immediate discovery of novel treatment strategies. One such strategy is the identification of collateral sensitivities, wherein evolution under a first drug induces susceptibility to a second. Here, we report that sequential ...
An understanding of fitness costs and compensatory evolution should allow us to make better quantitative predictions about the rate and trajectory of the evolution of resistance to new and old drugs. Abstract Most antibiotic resistance mechanisms are associated with a fitness cost that is typically obse...