Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. In AML, the bone marrow makes abnormal red blood cells, platelets, or myeloblasts (a type of immature white blood cell). These abnormal cells are called “blasts” and are the leukemia cells. These cells ...
ACUTE myeloid leukemiaPATIENTS2003 Nature Publishing Groupdoi:10.1038/sj.leu.2402787M L SmithJ SnaddonM NeatM Cambal-ParralesR ArchT A ListerJ FitzgibbonLeukemiaSmith M L,Snaddon J,Neat M,et a1.Mutation of BRAF is uncommon in AML FAB type M1 and M2. Leukemia,2003,17:274--275....
Leukemia is cancer of the blood or bone marrow. Bone marrow produces blood cells, so individuals who have leukemia have an abnormal production of blood cells. Usually the abnormality is with the leukocytes, or white blood cells, and is the result of damage to the DNA of...
Leukemia is categorized as acute or chronic based on the rate of proliferation of the leukemic cells. There are four major types of leukemia, two each for the predominant cell lineages—chronic/acute myeloid leukemia (CML and AML) and chronic/acute lymphocytic leukemia (CLL, ALL).3Cases of ca...
Acute myeloid leukemia (AML) is a typically lethal molecularly heterogeneous disease, with few broad-spectrum therapeutic targets. Unusually, most AML retain wild-type TP53, encoding the pro-apoptotic tumor suppressor p53. MDM2 inhibitors (MDM2i), which
Common symptoms of childhood leukemia include fever with or without an infection; bone pain, joint pain, or limpness; feeling weak or tired; and easy bruising. Common Types of Childhood Leukemia Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are the 2 most common types ...
Through a clustered regularly insterspaced short palindromic repeats (CRISPR) screen to identify mitochondrial genes necessary for the growth of acute myeloid leukemia (AML) cells, we identified the mitochondrial outer membrane prote...
Acute myeloid leukemia (AML) is a serious, life-threatening, and hardly curable hematological malignancy that affects the myeloid cell progenies and challenges patients of all ages but mostly occurs in adults. Although several therapies are available including chemotherapy, allogeneic hematopoietic stem ce...
The AML1/Runx1 transcription factor and its heterodimerization partner CBFβ are essential regulators of myeloid differentiation. The chromosomal translocation t(8;21), fusing the DNA binding domain of AML1 to the corepressor eight-twenty-one (ETO), is f
TIFA is the smallest known protein containing an FHA domain. The FHA domain binds phospho-threonine with high specificity. In acute myeloid leukemia (AML), AURKA indirectly activates the NF-κB pathway by phosphorylating TIFA at T9 (Table1) [62]. Unphosphorylated TIFA exists as a dimer; howev...