髓系MPO表达包括细胞化学检测≥MPO阳性为3%,流式细胞术≥为10%,明确MPO表达于白血病细胞而不仅仅是残存的正常母细胞。没有MPO表达的AML的髓系分化也可以通过至少两种髓系相关标志物(CD13、CD33和/或CD117)的强表达来证实。其中一个细胞群(或罕见两个细胞群)可能少于20%。其中一个细胞群可以少到什么程度,并且仍然...
Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: no difference in related compared with unrelated transplant in first complete remission. J Clin Oncol J Am Soc Clin Oncol. 2004;22:2816–25. Article Google Scholar Gassas A, Sung L,...
在本次ASH年会上,陆道培医院曹星玉教授的一项研究《一次移植后复发的T急性淋巴细胞白血病或淋巴母细胞淋巴瘤接受CD7 CAR-T治疗后进行二次造血干细胞移植》入选壁报展示,《肿瘤瞭望》特邀曹星玉教授对该研究进行介绍与点评。 研究背景 T急性淋巴...
6.IKZF1 plus,是指IKZF1缺失合并CDKN2A、CDKN2B、PAX5或PAR1缺失,且不存在ERG缺失,同样的,这些异常伴22q11.22缺失尤其与预后不良相关。然而,存在DUX4重排伴IKZF1改变并不意味着预后不良。Mullighan CG, Su X, Zhang J, et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl ...
结论:急性白血病骨髓基质细胞间通讯功能较正常骨髓基质细胞明显减低。【关键词】急性白血病Connexin43ExpressionandInteracellularCommunicatingFunctioninAcuteLeukemiaBoneMarrowStromaCellsLIUYao*,ZHANGXi*,SIYingJian,GAOLei,GAOLi,CHENXingHuaDepartmentofHematology,XinqiaoHospital,TheThirdMilitaryMedicalUniversity,Chongqing400037,...
Though My+ALL had myeloid markers, no significant difference was found between My+ALL and ALL, it might be supposed that their therapy could be the same. Key words acute leukemia; Ly+AML; My+ALL; AML; ALL; BAL 中国实验血液学杂志 J Exp Hematol 2007; 15(2)急性白血病Ly+AML型和My+ALL...
Just like RT-qPCR, IG/TR NGS requires a diagnostic sample to identify the leukemia-specific index rearrangements that are monitored throughout therapy; however, design and testing of patient-specific oligonucleotides is avoided because the same multiplex PCR assay can be used for identification and ...
白血病-- AML ALL 骨髓移植(英文版).ppt,* * * ALL, acute lymphoblastic leukemia; BMT CTN, Blood and Marrow Transplant Clinical Trials Network; CALGB, Cancer and Leukemia Group B; CIBMTR, Center for International Blood and Marrow Transplant Research; CLL,
2 Notwithstanding these properties, leukemia stem cells are operatively defined by their ability to propagate disease in naïve hosts at limiting dilution, typically referred to in the literature as leukemia-initiating cells (LICs). We and others, have shown that LICs in both mouse and human ...
12 High OPAL1 expression was shown to be highly predictive of a favorable outcome in the total ALL group, but also in ALL subgroups, such as T-lineage ALL and t(12;21)/TEL-AML1–positive B-lineage ALL. Finally, low OPAL1 was significantly related to induction failures.12 To validate ...