This increase in cell death rates is strongly suppressed in embryos coinjected with p53 mRNA and perp MO (Figure 3h, k), but not in embryos coinjected with p53 mRNA and perp 4 mm MO (Figure 3i, k), indicating that perp is required to mediate p53-induced apoptosis. Along the same ...
Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice. Oncogene. 2000;19(5):649–60. CAS PubMed Google Scholar Muller M, et al. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage...
et al. Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB. Int J Cancer 123, 357–364, https://doi.org/10.1002/ijc.23498 (2008). Article CAS PubMed Google Scholar Download references Acknowledgements We want to thank Dr. Martin ...
Inhibition of Hsp90 has previously been shown to sensitise tumour cells to ionising radiation in other types of cancer. Hsp90 is involved in a wide range of cellular processes and studies in yeast have identified more than 600 putative Hsp90 substrates (Zhao et al. 2005). Finding the ...
Structural modelling predicts XLS to be highly similar to XRCC4 and XLF, and depletion of XLS delays ionising radiation (IR)-induced DNA DSB repair. Moreover, XLS is associated with other core c-NHEJ factors. Our data strongly suggest that c9orf142/XLS represents a novel c-NHEJ component ...
The load of DNA double-strand breaks (DSBs) induced in the genome of higher eukaryotes by different doses of ionizing radiation (IR) is a key determinant of DSB repair pathway choice, with homologous recombination (HR) and ATR substantially gaining groun