Blazer-Yost BL, Hughes CL, Nolan PL: Protein prenylation is required for aldosterone-stimulated Naϩ transport. Am J Physiol 272:C1928-C1935, 1997Blazer-Yost, B.L., Hughes, C.L., and Nolan, P.L. (1997). Protein prenylation is required for aldosterone-stimulated Naϩ transport. Am....
摘要: Examines the importance of protein prenylation and subsequent protein methylations that may be involved in aldosterone-stimulated sodium flux. Inhibition of the natriferic effect of aldosterone by lovastatin; Effects on N-acetyl-S-geranylgeranyl-L-cysteine on epithelial cell protein content....
This NGAL-mediated activity relied on NFB (nuclear factor-B) activation, confirmed by the use of the NFB-specific inhibitor BAY11-7082, which prevented the effect of both aldosterone and NGAL on collagen type I production. In conclusion, NGAL, a downstream MR activation target, is a key ...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook RnBP (redirected fromRenin Binding Protein) AcronymDefinition RnBPRenin Binding Protein RnBPRichmond National Battlefield Park(Virginia) RnBPRegistered Nurse Bridge Program(est. 2004) ...
We examined the contribution of transforming growth factor (TGF)--T-cell signaling to aldosterone (aldo)/salt-induced fibrosis in the kidneys and the hearts of FVB/N wild-type (WT) or transgenic (Tg) mice expressing a dominant-negative TGF- type II receptor in T cells (hCD2-kTRII). Ani...
The decrease in amount of ACE2 protein was confirmed by Western blotting, and IMD-1041 also prevented the decrease in ACE2. The administration of spironolactone also abolished the effects of aldosterone. Conclusion Our results suggest that aldosterone induces kidney injury via activation of NFκB ...
In this study, we focused on the relationship between aldosterone and NOX1 expression in vascular smooth muscle cells (VSMCs). For the first time, with the use of specific inhibitors of protein kinase C (PKC), we report that PKCδ mediates upregulation of NOX1 i...
Serum inflammatory factors, including C-reactive protein, interleukin-6, tumour necrosis factor-αand monocyte chemoattractant protein-1, increased significantly in the aldosterone group, calcified alone group, and calcification+aldosterone group, than...
Aldosterone-producing adenomas (APAs) are responsible for half the cases of primary aldosteronism, and about half have mutations of the G protein-activated inward rectifying potassium channel Kir3.4. Under basal conditions, the adrenal zona glomerulosa cells are hyperpolarized with negative resting ...
NCC function is tightly linked to multisite phosphorylation of NCC, a process that is dependent on increased activity of the WNK-SPAK signaling network6 by the hormones ANGII, aldosterone and AVP2,7,8,9. Ubiquitylation also plays a major role in modulating NCC function; but the majority of ...