Human adipose tissue has an important protein It is well known that human adipose tissue is a PAI-1Arner, P
Bone marrow adipose tissue (BMAT) comprises >10% of total adipose mass, yet unlike white or brown adipose tissues (WAT or BAT) its metabolic functions remain unclear. Herein, we address this critical gap in knowledge. Our transcriptomic analyses revealed that BMAT is distinct from WAT and BAT,...
Aortic Carboxypeptidase-Like Protein (ACLP): What is a Protein with a Name Like That Doing in Adipose Tissue? 来自 NCBI 喜欢 0 阅读量: 35 作者:A Sorisky,A Gagnon,K Abaiian 摘要: Departments of Medicine and Biochemistry, Microbiology & Immunology, Ottawa Health Research Institute, Ottawa ...
Interactions between adipose tissue, liver and immune system are at the center of metabolic dysfunction-associated steatotic liver disease and type 2 diabetes. To address the need for an accurate in vitro model, we establish an interconnected microphysio
Z. et al. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metab. 17, 798–805 (2013). CAS PubMed Google Scholar Cypess, A. M. et al. Anatomical localization, gene expression profiling and functional ...
Low grade inflammation is a key feature of central obesity, characterized by elevated plasma levels of C-reactive protein (CRP). We hypothesize that visceral adipose tissue contributes to systemic concentrations of CRP. In 2410 patients (1729 men and 681 women) with vascular diseases, subcutaneous ...
Angiopoietin-like protein-4 (ANGPTL4) was identified in 2000 as a secreted plasma protein expressed in adipose tissue [1] and liver [2]. ANGPTL4 is induced by fasting in both white adipose tissue and liver under the regulation of peroxisome proliferator-activated receptors (PPAR) [1]. ANGPTL...
Indeed, there are only few reports of UCP1 protein (as compared to UCP1 mRNA) in white adipose tissue; it has mainly been detected by immunohistochemistry, and it is found generally in islet-like accumulations of cells. Thus, although immense interest has been vested in the browning ...
Brown adipose tissue (BAT) primarily evolved as a source of nonshivering thermogenesis that generates endogenous heat, which sustains body temperature in the face of cold exposure1. In the past decades, BAT thermogenesis guided by uncoupling protein 1 (UCP1) has been well-characterized and involves...
Inhibition of AMPK is tightly associated with metabolic perturbations upon over nutrition, yet the molecular mechanisms underlying are not clear. Here, we demonstrate the serine/threonine-protein phosphatase 6 regulatory subunit 3, SAPS3, is a negative regulator of AMPK. SAPS3 is induced under high...