White adipose tissue (WAT)Our previous studies found that safflower yellow (SY) and its main component hydroxysafflor yellow A (HSYA) could alleviate obesity and improve leptin resistance in high-fat diet (HFD) induced obese mice. Therefore, our present study aimed to investigate whether the ...
Safflower Yellow and Its Main Component HSYA Alleviate Diet-Induced Obesity in Mice: Possible Involvement of the Increased Antioxidant Enzymes in Liver and Adipose Tissue. Front Pharmacol. 2020 Apr 21; 11:482. doi: 10.3389/fphar.2020.00482. 作者 严克敏,王欣,潘慧,王林杰,阳洪波,刘美娟,朱惠娟*,龚凤...
In case of urine, samples were additionally normalized to account for diurnal dilution using probabilistic quotient normalization70. Afterwards all metabolites were log2-transformed. Finally, robust multivariate outlier exclusion based on principle component analyses was performed. After pre-processing 475 ...
A Principal Component Analysis (PCA) was performed to identify patterns for the consumption of the main food groups among the participants using the “FactoMineR” package [27] in R [26]. A method to reduce variables (cos2> 0.2) was used to identify the most important parameters in the dis...
RP and its main component, puerarin, increased mitochondrial biogenesis and myotube hypertrophy in C2C12 cells. The present study demonstrates that RP can prevent diet-induced obesity, glucose tolerance, and skeletal muscle atrophy in mouse models of obesity. The mechanism responsible for the effect ...
The PIM-2 kinase is an essential component of the UV damage response that acts upstream to E2F-1 and ATM. J Biol Chem. 2013; 288: 21770 - 21783. Hubbi ME, Hu H, Kshitiz NF, Gilkes DM, Semenza GL. Sirtuin-7 Inhibits the Activity of Hypoxia-Inducible Factors. J Biol Chem. ...
(A) The score plot for the first two predictive component (t[1] and t0[1]) discriminates plasma metabolite profiles between healthy control and Graves’ disease groups. Red circle is T2 ellipse indicating 0.05 as significance level. (B) 999 times random permutation plot with 4 components on...
1) two principal component analyses (PCA) were performed with the two datasets (here the expression table of the DEG list and the table of metabolite measurements), 2) the components of each PCA were weighed by the first eigenvalue to avoid biasing the MFA towards gene expression (several hu...
However, PIDs are broadly classified as follows according to the component of the immune system affected: T-cell immunodeficiency, e.g., defects in the IFN-γ/IL-12 pathway and mutations in the autoimmune regulator (AIRE) gene. B-cell (antibody-mediated) immunodeficiency: gamma-globulinemia, ...
significant when the NO-dependent component of endothelial vasodilation was isolated (Figure 4F). Since NOX2 activity results in superoxide production, we evaluated in situ ROS generation in vascular sections from some obese subjects (n= 11). There were clear differences in ROS generation in ...