White adipose tissue (WAT)Our previous studies found that safflower yellow (SY) and its main component hydroxysafflor yellow A (HSYA) could alleviate obesity and improve leptin resistance in high-fat diet (HFD) induced obese mice. Therefore, our present study aimed to investigate whether the ...
Safflower Yellow and Its Main Component HSYA Alleviate Diet-Induced Obesity in Mice: Possible Involvement of the Increased Antioxidant Enzymes in Liver and Adipose Tissue. Front Pharmacol. 2020 Apr 21; 11:482. doi: 10.3389/fphar.2020.00482. 作者 严克敏,王欣,潘慧,王林杰,阳洪波,刘美娟,朱惠娟*,龚凤...
Besides providing energy storage, one of the main function of lipidsis to also serve as a main component in insulating and regulating temperature within organisms. Adipose tissue (mainly consisting of fat cells) is an insulator against heat loss. Also, in colder climates the insulating properties ...
Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. Although cholesterol is a major component of the CNS, there is little information on how or whether a change in sterol flux across the blood-brain barrier ....
A Principal Component Analysis (PCA) was performed to identify patterns for the consumption of the main food groups among the participants using the “FactoMineR” package [27] in R [26]. A method to reduce variables (cos2> 0.2) was used to identify the most important parameters in the dis...
RP and its main component, puerarin, increased mitochondrial biogenesis and myotube hypertrophy in C2C12 cells. The present study demonstrates that RP can prevent diet-induced obesity, glucose tolerance, and skeletal muscle atrophy in mouse models of obesity. The mechanism responsible for the effect ...
The PIM-2 kinase is an essential component of the UV damage response that acts upstream to E2F-1 and ATM. J Biol Chem. 2013; 288: 21770 - 21783. Hubbi ME, Hu H, Kshitiz NF, Gilkes DM, Semenza GL. Sirtuin-7 Inhibits the Activity of Hypoxia-Inducible Factors. J Biol Chem. ...
An important component of these signaling networks is GADD45 proteins which are especially well characterized in T cell [42]. That is probably why gene GADD45G is up regulated in LFE group. Another up regulated gene in LFE animals and can be associated with inflammatory response is RHOB, a ...
However, PIDs are broadly classified as follows according to the component of the immune system affected: T-cell immunodeficiency, e.g., defects in the IFN-γ/IL-12 pathway and mutations in the autoimmune regulator (AIRE) gene. B-cell (antibody-mediated) immunodeficiency: gamma-globulinemia, ...
multivariate outlier exclusion based on principle component analyses was performed. After pre-processing 475 plasma and 558 urine metabolites remained for the statistical analyses. Statistical Analysis Continuous data are expressed as median (25th; 75th quartile) and nominal data are expressed as ...