Histone acetylation is a predominant active chromatin mark deposited by histone acetyltransferases (HATs) that transfer the acetyl group from acetyl coenzyme A (acetyl-CoA) to lysine ε-amino groups in histones. GENERAL CONTROL NON-REPRESSED PROTEIN 5 (GCN5) is one of the best-characterized HATs ...
Reactions that have been published in the literature using DMAP fall into, but are not limited to, the following types of reactions: Acylation; Acetylation; Alkylation; Benzoylation; Bischler-Naperalski cyclization, Carbonylation; Carbo- diimidation; Cyclization; Dehydration; Esterificaton; Indole ...
Acylations are usually modulated by fatty acid metabolites1,2,4,30; for example, acetate induces acetylation31. Therefore, we determined whether isonicotinic acid (INA) or sodium isonicotinate (SIN) could induce Kinic. We applied a series of concentrations of INA or SIN to induce Kinicin HepG...
the method is of interest for the acylation of sterically hindered phenols. For example, mesitol can be smoothly acetylated with acetic anhydride/DMAP to 2,5-ditert-butylphenol and analogous compounds can be transformed into acyl derivatives of the ...
Flavivirus infection is tightly connected to host lipid metabolism. Here, we performed shotgun lipidomics of cells infected with neurotropic Zika, West Nile, and tick-borne encephalitis virus, as well as dengue and yellow fever virus. Early in infection
The data indicate that the short-term inhibition of brain PDH affects acetylation and/or succinylation of the brain proteins, that depends on the inhibitor potency, protein molecular mass, and acylation type. The homeostatic nature of these changes is implied by the stability of physiological ...
Why pyridine is used in acetylation? Pyridine isa reasonable nucleophile for carbonyl groupsand is often used as a catalyst in acylation reactions. The nitrogen atom in pyridine is nucleophilic because the lone pair of electrons on nitrogen cannot be delocalised around the ring. ...
This precursor is also able to be cleaved to shorter sequences (32, 21, and 11 amino acids), and all are able to activate the apelin receptor and are blocked by apelin receptor antagonists. This review summarizes the pharmacology of these ligands and the apelin receptor, highlights the ...
In all eukaryotes, acetylation of histone lysine residues correlates with transcription activation. Whether histone acetylation is a cause or consequence of transcription is debated. One model suggests that transcription promotes the recruitment and/or a
Indeed, histone H3 acetylated at lysine 9, 14, or 27 accumulates around transcription start sites (TSSs) and/or enhancers of tran- scriptionally active genes2. It has been shown that acetylation of different lysine residues in the N-terminal tail of H4 has distinct functions. Hyperacetylated ...