2.4. Cytomegalovirus and Transplant Patients HCMV is one of the most frequently encountered opportunistic viral pathogens in transplant patients: a primary infection can occur in seronegative individuals after organ transplantation while a latent infection can be reactivated in seropositive i...
The window of opportunity is closed with the rise of CDK activity, but replication initiation can only occur, when DDK-activity is present. In a DDK- and CDK-dependent process, additional complexes bind to origins to form the pre-initiation (pre-IC) complex. This includes the Cdc45 (45),...
The resulting changes of muscle secretomes induced by exercise occur with a decent delay to allow de novo protein synthesis, inducing a moderately fast adaptation and (re)modeling response. One example is the immediate rise of muscle insulin-like growth factor 1 (IGF-1) mRNA after an exercise...
The tumor suppressor p53 is a hub protein involved in hundreds of interactions, the majority of which occur within its disordered N- and C-termini. Computational studies of this protein have focused on the mechanism by which it forms a stable structure upon binding each of its partners, ...
Secretions of the rabbit appendix are rich in bicarbonate and occur spontaneously and at a relatively rapid rate (1–12 mL/h). Therefore, it has been suggested that in rabbits, the appendix may have a major role in the regulation of pH in the cecum. However, similar data is not ...