structural analysis o structural clash structural data structural design of structural discontinu structural drilling structural elucidatio structural inspection structural mechanics structural mechanics structural model anal structural model aspe structural motif structural parts structural plasticity structural precis...
may code for both a large and one or more small proteins translated from annotated coding sequences (CDSs) and unannotated alternative open reading frames (named alternative ORFs or altORFs), respectively, but the stoichiometry between large and small proteins translated from a same gene is ...
Tryptophan C-mannosylation stabilizes a structural motif called the tryptophan ladder, which is most commonly found in proteins bearing a thrombospondin repeat (TSR) domain6,7,8. This domain almost universally contains a WxxWxxC motif, which is recognized and modified by DPY19 homologs5,9. ...
A、It is a structural component with specific spatial structure and function. B、It usually has characteristic amino acid sequences. C、Supersecondary structure with special function is motif. D、Motifs in some proteins consist of only a few amino acid residues. ...
Our ATR interactome exhibited a 55% enrichment (265/479) for proteins with (S/T-Q) motif, a potential targets of ATR phosphorylation, while such proteins represent only 22% (5137/17522) in the total phospho-proteins of the PhosphoSitePlus database34 (Supplementary Fig. 4b). Several of ...
the organization’s name changed to the Institute for the Study of Ancient Cultures, West Asia & North Africa, abbreviated as ISAC.The institute’s new logo features a lotus flower, which is found in ancient Assyrian, Mesopotamian, and Egyptian art, as well as being a decorative motif on th...
Previous experimental work has led to a proposed model of adsorption that involves an unusual clam-shell-like unhinging of the protein at an interface. Interestingly, there is no concomitant denaturation of the secondary structural elements of Rsn-2 with the large-scale transformation of its ...
EvoDiff可以生成高保真度,多样的并且结构上可行的蛋白质序列。更关键的是,生成结构的方法天生的无法生成disordered regions,而EvoDiff可以很好的完成这件事情,并且也能完成生成结构的方法擅长的诸如motif scaffolding之类的任务。 在序列维度设计的motivation 目前的SOTA,RFdiffusion [2]以及其他蛋白质设计的模型(FrameDiff ...
Their ability to pull down detectable amounts of endogenous CPC (Figure S1A) is indicated. (B) Cartoon of human INCENP and used INCENP deletion mutants. CEN, centromere-targeting domain interacting with Borealin and Survivin; IN, IN box interacting with Aurora B; PVVEI, HP1 binding motif; ...
Sequence analysis indicated that CRT1 contains a 'GHKL' (Gyrase, Hsp90, Histidine Kinase, MutL) ATPase motif15 and an S5-fold domain (383aa–458aa)16. These domains are characteristic of MORC (Microchidia) proteins, a subset of the GHKL ATPase superfamily16. MORC proteins are widely ...